Synthesis of control unit for future biocomputer
Abstract Background Synthesis of a variety of biological circuits for specific functional purposes has made a tremendous progress in recent years. The ultimate goal of combining molecular biology and engineering is to realize a functional biocomputer. To address this challenge, all previous efforts...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Journal of Biological Engineering |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13036-018-0109-4 |
| _version_ | 1819265522525536256 |
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| author | Chun-Liang Lin Ting-Yu Kuo Wei-Xian Li |
| author_facet | Chun-Liang Lin Ting-Yu Kuo Wei-Xian Li |
| author_sort | Chun-Liang Lin |
| collection | DOAJ |
| description | Abstract Background Synthesis of a variety of biological circuits for specific functional purposes has made a tremendous progress in recent years. The ultimate goal of combining molecular biology and engineering is to realize a functional biocomputer. To address this challenge, all previous efforts work toward building up the bio-computer as the ultimate goal. To this aim, there should be a key module, named control unit (CU), to direct a serious of logic or arithmetic operations within the processor. Methods This research task develops a bio-CU to work with a bio-ALU, which is realized from the combination of previously developed genetic logic gates to fulfill the kernel function of CPU as those done in the silicon computer. Results A possible framework of the bio-CPU has demonstrated how to connect a bio-CU with a bio-ALU to conduct a fetch-decode-execute cycle of a macro instruction. It presents not only capability of 4-bit full adder but coordination of related modules in biocomputer. Conclusions We have demonstrated computer simulation for applications of the genetic circuits in biocomputer construction. It’s expected to inspire follow-up study to synthesize potential configurations of the future biocomputer. |
| first_indexed | 2024-12-23T20:46:43Z |
| format | Article |
| id | doaj.art-791f99c595ab48eb9871f35221704590 |
| institution | Directory Open Access Journal |
| issn | 1754-1611 |
| language | English |
| last_indexed | 2024-12-23T20:46:43Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj.art-791f99c595ab48eb9871f352217045902022-12-21T17:31:47ZengBMCJournal of Biological Engineering1754-16112018-08-0112111610.1186/s13036-018-0109-4Synthesis of control unit for future biocomputerChun-Liang Lin0Ting-Yu Kuo1Wei-Xian Li2Department of Electrical Engineering, National Chung Hsing UniversityDepartment of Electrical Engineering, National Chung Hsing UniversityDepartment of Electrical Engineering, National Chung Hsing UniversityAbstract Background Synthesis of a variety of biological circuits for specific functional purposes has made a tremendous progress in recent years. The ultimate goal of combining molecular biology and engineering is to realize a functional biocomputer. To address this challenge, all previous efforts work toward building up the bio-computer as the ultimate goal. To this aim, there should be a key module, named control unit (CU), to direct a serious of logic or arithmetic operations within the processor. Methods This research task develops a bio-CU to work with a bio-ALU, which is realized from the combination of previously developed genetic logic gates to fulfill the kernel function of CPU as those done in the silicon computer. Results A possible framework of the bio-CPU has demonstrated how to connect a bio-CU with a bio-ALU to conduct a fetch-decode-execute cycle of a macro instruction. It presents not only capability of 4-bit full adder but coordination of related modules in biocomputer. Conclusions We have demonstrated computer simulation for applications of the genetic circuits in biocomputer construction. It’s expected to inspire follow-up study to synthesize potential configurations of the future biocomputer.http://link.springer.com/article/10.1186/s13036-018-0109-4Synthetic biologyGenetic logic circuitArithmetic and logical unitControl unit |
| spellingShingle | Chun-Liang Lin Ting-Yu Kuo Wei-Xian Li Synthesis of control unit for future biocomputer Journal of Biological Engineering Synthetic biology Genetic logic circuit Arithmetic and logical unit Control unit |
| title | Synthesis of control unit for future biocomputer |
| title_full | Synthesis of control unit for future biocomputer |
| title_fullStr | Synthesis of control unit for future biocomputer |
| title_full_unstemmed | Synthesis of control unit for future biocomputer |
| title_short | Synthesis of control unit for future biocomputer |
| title_sort | synthesis of control unit for future biocomputer |
| topic | Synthetic biology Genetic logic circuit Arithmetic and logical unit Control unit |
| url | http://link.springer.com/article/10.1186/s13036-018-0109-4 |
| work_keys_str_mv | AT chunlianglin synthesisofcontrolunitforfuturebiocomputer AT tingyukuo synthesisofcontrolunitforfuturebiocomputer AT weixianli synthesisofcontrolunitforfuturebiocomputer |