| Summary: | Bacground/Aim. The therapy with intravesical instillation of bacillus
Calmette-Guérin (BCG) after transurethral resection (TUR) of tumor is the
gold standard of treatment of non-muscle invasive bladder cancer (NMIBC). The
role and importance of BCG intravesical therapy in various shape of tumors,
were confirmed by our previous investigation. The aim of this study was to
examine whether incidence of recurrence and tumor regression differs
depending on sex and age of patients. Methods. This study included a total of
899 patients suffering from NIMBC, treated at our institution from January 1,
2007 to March 1, 2013. Two groups of patients were formed: patients underwent
TUR + BCG therapy (the group I) and the group II with patients in whom TUR
was performed as only therapy. These two groups of patients were divided into
subgroups of respondents male and female, age 60 years or younger and older
than 60 years. Statistical analysis was performed using χ2 test and the
Kolmogorov-Smirnov test. Results. This research suggests that if the
frequency of recurrence is seen as the only parameter, considering all the
subjects, the lowest recurrence rate was determined in the male subjects,
aged 60 years and younger who had received BCG after TUR. A high statistical
significance was found in the incidence of recurrence in patients younger
than 60 years, depending on the response to the therapy, while in those older
than 60 years, the difference was at the level of statistical significance.
This can be attributed to a certain degree of infravesical obstruction in
older men. Conclusions. Sex and age of patients may have a significant
influence on the course and outcome of NMIBC. The disease has the most
malignant and most aggressive behavior when present in males older than 60
years.
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