Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation
Vitamin D has been proposed as a therapeutic strategy in pancreatic cancer, yet evidence for an effect of dietary vitamin D on pancreatic cancer is ambiguous, with conflicting data from human epidemiological and intervention studies. Here, we tested the role of dietary vitamin D in the in vivo conte...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2017.00133/full |
| _version_ | 1819263625864413184 |
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| author | James Dooley James Dooley Vasiliki Lagou Vasiliki Lagou Nathalie Heirman Nathalie Heirman Tom Dresselaers Uwe Himmelreich Adrian Liston Adrian Liston |
| author_facet | James Dooley James Dooley Vasiliki Lagou Vasiliki Lagou Nathalie Heirman Nathalie Heirman Tom Dresselaers Uwe Himmelreich Adrian Liston Adrian Liston |
| author_sort | James Dooley |
| collection | DOAJ |
| description | Vitamin D has been proposed as a therapeutic strategy in pancreatic cancer, yet evidence for an effect of dietary vitamin D on pancreatic cancer is ambiguous, with conflicting data from human epidemiological and intervention studies. Here, we tested the role of dietary vitamin D in the in vivo context of the well-characterized Ela1-TAg transgenic mouse model of pancreatic acinar cell carcinoma. Through longitudinal magnetic resonance imaging of mice under conditions of either dietary vitamin D deficiency (<5 IU/kg vitamin D) or excess (76,500 IU/kg vitamin D), compared to control diet (1,500 IU/kg vitamin D), we measured the effect of variation of dietary vitamin D on tumor kinetics. No measurable impact of dietary vitamin D was found on pancreatic acinar cell carcinoma development, growth or mortality, casting further doubt on the already equivocal data supporting potential therapeutic use in humans. The lack of any detectable effect of vitamin D, within the physiological range of dietary deficiency or supplementation, in this model further erodes confidence in vitamin D as an effective antitumor therapeutic in pancreatic acinar cell carcinoma. |
| first_indexed | 2024-12-23T20:16:34Z |
| format | Article |
| id | doaj.art-7921f5b56bca450794c869477479135e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T20:16:34Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7921f5b56bca450794c869477479135e2022-12-21T17:32:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2017-06-01710.3389/fonc.2017.00133277261Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or SupplementationJames Dooley0James Dooley1Vasiliki Lagou2Vasiliki Lagou3Nathalie Heirman4Nathalie Heirman5Tom Dresselaers6Uwe Himmelreich7Adrian Liston8Adrian Liston9Translational Immunology Laboratory, VIB, Leuven, BelgiumDepartment of Microbiology and Immunology, KU Leuven, Leuven, BelgiumTranslational Immunology Laboratory, VIB, Leuven, BelgiumDepartment of Microbiology and Immunology, KU Leuven, Leuven, BelgiumTranslational Immunology Laboratory, VIB, Leuven, BelgiumDepartment of Microbiology and Immunology, KU Leuven, Leuven, BelgiumDepartment of Imaging and Pathology, KU Leuven, Leuven, BelgiumDepartment of Imaging and Pathology, KU Leuven, Leuven, BelgiumTranslational Immunology Laboratory, VIB, Leuven, BelgiumDepartment of Microbiology and Immunology, KU Leuven, Leuven, BelgiumVitamin D has been proposed as a therapeutic strategy in pancreatic cancer, yet evidence for an effect of dietary vitamin D on pancreatic cancer is ambiguous, with conflicting data from human epidemiological and intervention studies. Here, we tested the role of dietary vitamin D in the in vivo context of the well-characterized Ela1-TAg transgenic mouse model of pancreatic acinar cell carcinoma. Through longitudinal magnetic resonance imaging of mice under conditions of either dietary vitamin D deficiency (<5 IU/kg vitamin D) or excess (76,500 IU/kg vitamin D), compared to control diet (1,500 IU/kg vitamin D), we measured the effect of variation of dietary vitamin D on tumor kinetics. No measurable impact of dietary vitamin D was found on pancreatic acinar cell carcinoma development, growth or mortality, casting further doubt on the already equivocal data supporting potential therapeutic use in humans. The lack of any detectable effect of vitamin D, within the physiological range of dietary deficiency or supplementation, in this model further erodes confidence in vitamin D as an effective antitumor therapeutic in pancreatic acinar cell carcinoma.http://journal.frontiersin.org/article/10.3389/fonc.2017.00133/fullpancreatic cancervitamin Din vivopancreatic acinar carcinomamagnetic resonance imaging |
| spellingShingle | James Dooley James Dooley Vasiliki Lagou Vasiliki Lagou Nathalie Heirman Nathalie Heirman Tom Dresselaers Uwe Himmelreich Adrian Liston Adrian Liston Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation Frontiers in Oncology pancreatic cancer vitamin D in vivo pancreatic acinar carcinoma magnetic resonance imaging |
| title | Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation |
| title_full | Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation |
| title_fullStr | Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation |
| title_full_unstemmed | Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation |
| title_short | Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation |
| title_sort | murine pancreatic acinar cell carcinoma growth kinetics are independent of dietary vitamin d deficiency or supplementation |
| topic | pancreatic cancer vitamin D in vivo pancreatic acinar carcinoma magnetic resonance imaging |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2017.00133/full |
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