Adenylyl-Sulfate Kinase (Met14)-Dependent Cysteine and Methionine Biosynthesis Pathways Contribute Distinctively to Pathobiological Processes in Cryptococcus neoformans

Adenylyl-Sulfate Kinase (Met14)-Dependent Cysteine and Methionine Biosynthesis Pathways Contribute Distinctively to Pathobiological Processes in Cryptococcus neoformans

ABSTRACT Blocking of nutrient uptake and amino acid biosynthesis are considered potential targets for next-generation antifungal drugs against pathogenic fungi, including Cryptococcus neoformans. In this regard, the sulfate assimilation pathway is particularly attractive, as it is only present in eu...

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Bibliographic Details
Main Authors: Seung-Heon Lee, Yu-Byeong Jang, Yeseul Choi, Yujin Lee, Bich Na Shin, Han-Seung Lee, Jong-Seung Lee, Yong-Sun Bahn
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
sulfur amino acids
sulfate assimilation pathway
Met14
Met3
virulence
fungal pathogens
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00685-23

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