ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS
Barrett’s esophagus is considered as a predictor of esophageal adenocarcinoma with multistage neoplastic progression at present time. The research assessed an expression of microRNA-21 in 25 patients with different degree of metaplasia and dysplasia of mucous coat of esophagus. The level of expressi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Pavlov First Saint Petersburg State Medical University
2016-08-01
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| Series: | Вестник хирургии имени И.И. Грекова |
| Subjects: | |
| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/263 |
| _version_ | 1797877724161769472 |
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| author | A. Z. Tsitskarava M. I. Zaraiskiy D. I. Vasilevskiy A. S. Lapshin V. F. Popova A. A. Smirnov M. E. Lyubchenko |
| author_facet | A. Z. Tsitskarava M. I. Zaraiskiy D. I. Vasilevskiy A. S. Lapshin V. F. Popova A. A. Smirnov M. E. Lyubchenko |
| author_sort | A. Z. Tsitskarava |
| collection | DOAJ |
| description | Barrett’s esophagus is considered as a predictor of esophageal adenocarcinoma with multistage neoplastic progression at present time. The research assessed an expression of microRNA-21 in 25 patients with different degree of metaplasia and dysplasia of mucous coat of esophagus. The level of expression of microRNA depended on the presence and degree of expression of neoplastic changes of mucous coat of esophagus. The expression rising of microRNA was noted in patients with columnar-celled metaplasia and intraepithelial neoplasia and in case of esophageal adenocarcinoma. The treatment strategy could be determined by the method of estimation of the level of microRNA expression in biopsy material from mucous coat of esophagus in patients with gastroesophageal reflux disease and using other criteria. |
| first_indexed | 2024-04-10T02:22:47Z |
| format | Article |
| id | doaj.art-7926152075e14ccf8a38d9f127ca3a2b |
| institution | Directory Open Access Journal |
| issn | 0042-4625 |
| language | Russian |
| last_indexed | 2024-04-10T02:22:47Z |
| publishDate | 2016-08-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj.art-7926152075e14ccf8a38d9f127ca3a2b2023-03-13T08:09:10ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252016-08-011754131410.24884/0042-4625-2016-175-4-13-14262ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUSA. Z. Tsitskarava0M. I. Zaraiskiy1D. I. Vasilevskiy2A. S. Lapshin3V. F. Popova4A. A. Smirnov5M. E. Lyubchenko6I.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityI.P.Pavlov First Saint Petersburg State Medical UniversityBarrett’s esophagus is considered as a predictor of esophageal adenocarcinoma with multistage neoplastic progression at present time. The research assessed an expression of microRNA-21 in 25 patients with different degree of metaplasia and dysplasia of mucous coat of esophagus. The level of expression of microRNA depended on the presence and degree of expression of neoplastic changes of mucous coat of esophagus. The expression rising of microRNA was noted in patients with columnar-celled metaplasia and intraepithelial neoplasia and in case of esophageal adenocarcinoma. The treatment strategy could be determined by the method of estimation of the level of microRNA expression in biopsy material from mucous coat of esophagus in patients with gastroesophageal reflux disease and using other criteria.https://www.vestnik-grekova.ru/jour/article/view/263micrornabarrett’s esophagusesophageal adenocarcinomacolumnar-celled metaplasiagastroesophageal reflux disease |
| spellingShingle | A. Z. Tsitskarava M. I. Zaraiskiy D. I. Vasilevskiy A. S. Lapshin V. F. Popova A. A. Smirnov M. E. Lyubchenko ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS Вестник хирургии имени И.И. Грекова microrna barrett’s esophagus esophageal adenocarcinoma columnar-celled metaplasia gastroesophageal reflux disease |
| title | ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS |
| title_full | ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS |
| title_fullStr | ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS |
| title_full_unstemmed | ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS |
| title_short | ROLE OF MICRORNA IN PREDICTING OF ADENOCARCINOMA DEVELOPMENT IN BARRETT’S ESOPHAGUS |
| title_sort | role of microrna in predicting of adenocarcinoma development in barrett s esophagus |
| topic | microrna barrett’s esophagus esophageal adenocarcinoma columnar-celled metaplasia gastroesophageal reflux disease |
| url | https://www.vestnik-grekova.ru/jour/article/view/263 |
| work_keys_str_mv | AT aztsitskarava roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT mizaraiskiy roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT divasilevskiy roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT aslapshin roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT vfpopova roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT aasmirnov roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus AT melyubchenko roleofmicrornainpredictingofadenocarcinomadevelopmentinbarrettsesophagus |