Structure-based virtual screening identified novel FOXM1 inhibitors as the lead compounds for ovarian cancer

Structure-based virtual screening identified novel FOXM1 inhibitors as the lead compounds for ovarian cancer

Ovarian cancer (OC) is a gynecological tumor with possibly the worst prognosis, its 5-year survival rate being only 47.4%. The first line of therapy prescribed is chemotherapy consisting of platinum and paclitaxel. The primary reason for treatment failure is drug resistance. FOXM1 protein has been f...

Full description

Bibliographic Details
Main Authors: Zi-Ying Zhou, Xiao-Yang Han, Lian-Qi Sun, Si-Yan Li, Si-Tu Xue, Zhuo-Rong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Chemistry
Subjects:
ovarian cancer
FOXM1
virtual screening
camptothecin
inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1058256/full

Similar Items

Similar Items