Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals
Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN)...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2015-08-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-641-en.pdf |
| _version_ | 1797679631096086528 |
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| author | Abdolvahab Alborzi Tayebeh Hashempour Mahboobe Mirhoseini nasim Adim Javad Moayedi Zahra Musavi Shahin Merat Gholam Reza Pouladfar Mehrdad Hallaji Farzaneh Ghassabi Arghavan Haj-Sheykholeslami |
| author_facet | Abdolvahab Alborzi Tayebeh Hashempour Mahboobe Mirhoseini nasim Adim Javad Moayedi Zahra Musavi Shahin Merat Gholam Reza Pouladfar Mehrdad Hallaji Farzaneh Ghassabi Arghavan Haj-Sheykholeslami |
| author_sort | Abdolvahab Alborzi |
| collection | DOAJ |
| description | Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms of the IL-28B gene can influence persistent antiviral response. Therefore, in this study, the frequency of genotypes of rs12979860 polymorphisms in two groups of healthy and HCV infected Iranian individuals were evaluated.
Materials & Methods: In this cross sectional study, PCR-RFLP method was used to evaluate the frequency of genotypes of rs12979860 polymorphisms in 105 healthy individuals and 105 chronic HCV infected patients.
Results: The frequency of rs12979860 genotypes in healthy individuals was CC: 50.5%, CT: 45.7%, and TT: 3.8%. In HCV infected patients it was CC: 22.9%, CT: 63.8%, and TT: 13.3%. The frequency of rs12979860 genotypes had significant difference between two groups however it is not associated with sex.
Conclusion: A significant difference was observed between healthy individuals and HCV infected patients in the frequency of rs12979860 genotypes. The favorable CC genotypes and unfavorable TT genotypes was more detected in healthy individuals and HCV infected patients, respectively. |
| first_indexed | 2024-03-11T23:17:36Z |
| format | Article |
| id | doaj.art-792d12695c4143d18e3e2cd5f9bf2fd6 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:36Z |
| publishDate | 2015-08-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-792d12695c4143d18e3e2cd5f9bf2fd62023-09-20T21:20:19ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232015-08-0152269277Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian IndividualsAbdolvahab Alborzi0Tayebeh Hashempour1Mahboobe Mirhoseini2nasim Adim3Javad Moayedi4Zahra Musavi5Shahin Merat6Gholam Reza Pouladfar7Mehrdad Hallaji8Farzaneh Ghassabi9Arghavan Haj-Sheykholeslami10 Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Biology Department, Payame Noor University, Iran. Biology Department, Payame Noor University, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms of the IL-28B gene can influence persistent antiviral response. Therefore, in this study, the frequency of genotypes of rs12979860 polymorphisms in two groups of healthy and HCV infected Iranian individuals were evaluated. Materials & Methods: In this cross sectional study, PCR-RFLP method was used to evaluate the frequency of genotypes of rs12979860 polymorphisms in 105 healthy individuals and 105 chronic HCV infected patients. Results: The frequency of rs12979860 genotypes in healthy individuals was CC: 50.5%, CT: 45.7%, and TT: 3.8%. In HCV infected patients it was CC: 22.9%, CT: 63.8%, and TT: 13.3%. The frequency of rs12979860 genotypes had significant difference between two groups however it is not associated with sex. Conclusion: A significant difference was observed between healthy individuals and HCV infected patients in the frequency of rs12979860 genotypes. The favorable CC genotypes and unfavorable TT genotypes was more detected in healthy individuals and HCV infected patients, respectively.http://jabs.fums.ac.ir/article-1-641-en.pdfhepatitis c virusinterlukin-28pcr-rflp |
| spellingShingle | Abdolvahab Alborzi Tayebeh Hashempour Mahboobe Mirhoseini nasim Adim Javad Moayedi Zahra Musavi Shahin Merat Gholam Reza Pouladfar Mehrdad Hallaji Farzaneh Ghassabi Arghavan Haj-Sheykholeslami Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals Journal of Advanced Biomedical Sciences hepatitis c virus interlukin-28 pcr-rflp |
| title | Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals |
| title_full | Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals |
| title_fullStr | Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals |
| title_full_unstemmed | Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals |
| title_short | Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals |
| title_sort | studying the frequency of favorable allele of rs12979860 polymorphism of il 28b in healthy and hcv infected iranian individuals |
| topic | hepatitis c virus interlukin-28 pcr-rflp |
| url | http://jabs.fums.ac.ir/article-1-641-en.pdf |
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