A pilot spectroscopy study of adversity in adolescents
Background: Childhood adversity is a global health problem affecting 25–50% of children worldwide. Few prior studies have examined the underlying neurochemistry of adversity in adolescents. This cross-sectional study examined spectroscopic markers of trauma in a cohort of adolescents with major depr...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-12-01
|
| Series: | Biomarkers in Neuropsychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666144621000149 |
| _version_ | 1818352830624301056 |
|---|---|
| author | A. Irem Sonmez Charles P. Lewis John D. Port Arjun P. Athreya Doo-Sop Choi Michael J. Zaccariello Julia Shekunov Caren J. Blacker Paul E. Croarkin |
| author_facet | A. Irem Sonmez Charles P. Lewis John D. Port Arjun P. Athreya Doo-Sop Choi Michael J. Zaccariello Julia Shekunov Caren J. Blacker Paul E. Croarkin |
| author_sort | A. Irem Sonmez |
| collection | DOAJ |
| description | Background: Childhood adversity is a global health problem affecting 25–50% of children worldwide. Few prior studies have examined the underlying neurochemistry of adversity in adolescents. This cross-sectional study examined spectroscopic markers of trauma in a cohort of adolescents with major depressive disorder (MDD) and healthy controls. We hypothesized that historical adversity would have a negative relationship with spectroscopic measures of glutamate metabolites in anterior cingulate cortex. Methods: Adolescent participants (aged 13–21) underwent a semi-structured diagnostic interview and clinical assessment, which included the self-report Childhood Trauma Questionnaire (CTQ), a 28-item assessment of childhood adversity. Proton magnetic resonance spectroscopy (1H-MRS) scans at 3 Tesla of an anterior cingulate cortex (ACC) voxel (8 cm3) encompassing both hemispheres were collected using a 2-dimensional J-averaged sequence to assess N-acetylaspartate (NAA), Glx (glutamate+glutamine) and [NAA]/[Glx] concentrations. Generalized linear models assessed the relationships between CTQ scores and metabolite levels in ACC. Results: Thirty-nine participants (17 healthy controls, 22 depressed participants) underwent 1H-MRS and completed the CTQ measures. There were decrements in [NAA]/[Glx] ratio in the ACC of participants with childhood adversity while no significant relationship between CTQ total score and any of the ACC metabolites was found in the combined sample. Exploratory results revealed a positive association between Glx levels and CTQ scores in depressed participants. Conversely the [NAA]/[Glx] ratio had a negative association with total CTQ scores in the depressed participants. Emotional Abuse Scale showed a significant negative relationship with [NAA]/[Glx] ratio in the combined sample when adjusted for depression severity. Conclusions: Our findings suggest that childhood adversity may impact brain neurochemical profiles. Further longitudinal studies should examine neurochemical correlates of childhood adversity throughout development and in populations with other psychiatric disorders. |
| first_indexed | 2024-12-13T18:59:52Z |
| format | Article |
| id | doaj.art-792e5aed8af1435bb9f3d430dd8ddacf |
| institution | Directory Open Access Journal |
| issn | 2666-1446 |
| language | English |
| last_indexed | 2024-12-13T18:59:52Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomarkers in Neuropsychiatry |
| spelling | doaj.art-792e5aed8af1435bb9f3d430dd8ddacf2022-12-21T23:34:42ZengElsevierBiomarkers in Neuropsychiatry2666-14462021-12-015100043A pilot spectroscopy study of adversity in adolescentsA. Irem Sonmez0Charles P. Lewis1John D. Port2Arjun P. Athreya3Doo-Sop Choi4Michael J. Zaccariello5Julia Shekunov6Caren J. Blacker7Paul E. Croarkin8Department of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA; Correspondence to: University of Minnesota, 2312 S 6th St, Minneapolis, MN 55454, USA.Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USADepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN 55905, USADepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN 55905, USADepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USADepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USABackground: Childhood adversity is a global health problem affecting 25–50% of children worldwide. Few prior studies have examined the underlying neurochemistry of adversity in adolescents. This cross-sectional study examined spectroscopic markers of trauma in a cohort of adolescents with major depressive disorder (MDD) and healthy controls. We hypothesized that historical adversity would have a negative relationship with spectroscopic measures of glutamate metabolites in anterior cingulate cortex. Methods: Adolescent participants (aged 13–21) underwent a semi-structured diagnostic interview and clinical assessment, which included the self-report Childhood Trauma Questionnaire (CTQ), a 28-item assessment of childhood adversity. Proton magnetic resonance spectroscopy (1H-MRS) scans at 3 Tesla of an anterior cingulate cortex (ACC) voxel (8 cm3) encompassing both hemispheres were collected using a 2-dimensional J-averaged sequence to assess N-acetylaspartate (NAA), Glx (glutamate+glutamine) and [NAA]/[Glx] concentrations. Generalized linear models assessed the relationships between CTQ scores and metabolite levels in ACC. Results: Thirty-nine participants (17 healthy controls, 22 depressed participants) underwent 1H-MRS and completed the CTQ measures. There were decrements in [NAA]/[Glx] ratio in the ACC of participants with childhood adversity while no significant relationship between CTQ total score and any of the ACC metabolites was found in the combined sample. Exploratory results revealed a positive association between Glx levels and CTQ scores in depressed participants. Conversely the [NAA]/[Glx] ratio had a negative association with total CTQ scores in the depressed participants. Emotional Abuse Scale showed a significant negative relationship with [NAA]/[Glx] ratio in the combined sample when adjusted for depression severity. Conclusions: Our findings suggest that childhood adversity may impact brain neurochemical profiles. Further longitudinal studies should examine neurochemical correlates of childhood adversity throughout development and in populations with other psychiatric disorders.http://www.sciencedirect.com/science/article/pii/S2666144621000149GlutamateNAA1H-MRSAnterior cingulateACCTrauma |
| spellingShingle | A. Irem Sonmez Charles P. Lewis John D. Port Arjun P. Athreya Doo-Sop Choi Michael J. Zaccariello Julia Shekunov Caren J. Blacker Paul E. Croarkin A pilot spectroscopy study of adversity in adolescents Biomarkers in Neuropsychiatry Glutamate NAA 1H-MRS Anterior cingulate ACC Trauma |
| title | A pilot spectroscopy study of adversity in adolescents |
| title_full | A pilot spectroscopy study of adversity in adolescents |
| title_fullStr | A pilot spectroscopy study of adversity in adolescents |
| title_full_unstemmed | A pilot spectroscopy study of adversity in adolescents |
| title_short | A pilot spectroscopy study of adversity in adolescents |
| title_sort | pilot spectroscopy study of adversity in adolescents |
| topic | Glutamate NAA 1H-MRS Anterior cingulate ACC Trauma |
| url | http://www.sciencedirect.com/science/article/pii/S2666144621000149 |
| work_keys_str_mv | AT airemsonmez apilotspectroscopystudyofadversityinadolescents AT charlesplewis apilotspectroscopystudyofadversityinadolescents AT johndport apilotspectroscopystudyofadversityinadolescents AT arjunpathreya apilotspectroscopystudyofadversityinadolescents AT doosopchoi apilotspectroscopystudyofadversityinadolescents AT michaeljzaccariello apilotspectroscopystudyofadversityinadolescents AT juliashekunov apilotspectroscopystudyofadversityinadolescents AT carenjblacker apilotspectroscopystudyofadversityinadolescents AT paulecroarkin apilotspectroscopystudyofadversityinadolescents AT airemsonmez pilotspectroscopystudyofadversityinadolescents AT charlesplewis pilotspectroscopystudyofadversityinadolescents AT johndport pilotspectroscopystudyofadversityinadolescents AT arjunpathreya pilotspectroscopystudyofadversityinadolescents AT doosopchoi pilotspectroscopystudyofadversityinadolescents AT michaeljzaccariello pilotspectroscopystudyofadversityinadolescents AT juliashekunov pilotspectroscopystudyofadversityinadolescents AT carenjblacker pilotspectroscopystudyofadversityinadolescents AT paulecroarkin pilotspectroscopystudyofadversityinadolescents |