Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature
Objective:Malignant mucosal melanomas of the head and neck comprise a very small portion of all melanomas, particularly in the oral cavity. These lesions are associated with high rates of local recurrence, distant metastasis, and a very poor 5-year survival rate; however, the clinical outcomes of mu...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2022-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/mucosal-melanoma-n-situ-of-the-oral-cavity-a-case-/54930
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| author | Polly Jasper W. Nicholas Jungbauer Nicolas S. Poupore Shaun A. Nguyen Jim Howell Brad W. Neville Terry A. Day |
| author_facet | Polly Jasper W. Nicholas Jungbauer Nicolas S. Poupore Shaun A. Nguyen Jim Howell Brad W. Neville Terry A. Day |
| author_sort | Polly Jasper |
| collection | DOAJ |
| description | Objective:Malignant mucosal melanomas of the head and neck comprise a very small portion of all melanomas, particularly in the oral cavity. These lesions are associated with high rates of local recurrence, distant metastasis, and a very poor 5-year survival rate; however, the clinical outcomes of mucosal melanoma in situ of the oral cavity are unclear. Therefore, we present a case report of mucosal melanoma in situ and a systematic review of the literature to shed light on this rare but important disease.Methods:PubMed, Scopus, and CINAHL were searched per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were only considered for inclusion if they described oral cavity melanoma in situ and documented specific data pertaining to treatment including modality, lesion size, or outcomes.Results:A total of 28 reported cases from the literature fulfilled the inclusion criteria, as well as one case from our own institution. Men comprised the majority (64.3%) of the cases, and the average age at presentation was 57.4 years. The hard palate was the most common location, and most cases were treated with surgical excision. Eight had no evidence of disease after a minimum of six months of follow-up, one reported spread to the cervical lymph nodes, and only one reported progression with distant metastasis.Conclusion:Oral mucosal melanoma in situ is a rare entity and most commonly treated with surgical excision. High rates of recurrence necessitate long term follow-up. Further studies may be useful to determine whether adjuvant therapy may play a role in reducing recurrence. |
| first_indexed | 2024-04-10T11:39:39Z |
| format | Article |
| id | doaj.art-792f0b52595f48789ac98661b663086b |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T11:39:39Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-792f0b52595f48789ac98661b663086b2023-02-15T16:17:34ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742022-09-0160316116910.4274/tao.2022.2022-7-513049054Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the LiteraturePolly Jasper0W. Nicholas Jungbauer1Nicolas S. Poupore2Shaun A. Nguyen3Jim Howell4Brad W. Neville5Terry A. Day6 Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States Carolinas Center for Oral and Facial Surgery, Greenville, SC, United States Director of Oral and Maxillofacial Pathology, HCA South Atlantic Division, Charleston, SC, United States Director of Head and Neck Oncology, Sarah Cannon National Group, Charleston, SC, United States Objective:Malignant mucosal melanomas of the head and neck comprise a very small portion of all melanomas, particularly in the oral cavity. These lesions are associated with high rates of local recurrence, distant metastasis, and a very poor 5-year survival rate; however, the clinical outcomes of mucosal melanoma in situ of the oral cavity are unclear. Therefore, we present a case report of mucosal melanoma in situ and a systematic review of the literature to shed light on this rare but important disease.Methods:PubMed, Scopus, and CINAHL were searched per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were only considered for inclusion if they described oral cavity melanoma in situ and documented specific data pertaining to treatment including modality, lesion size, or outcomes.Results:A total of 28 reported cases from the literature fulfilled the inclusion criteria, as well as one case from our own institution. Men comprised the majority (64.3%) of the cases, and the average age at presentation was 57.4 years. The hard palate was the most common location, and most cases were treated with surgical excision. Eight had no evidence of disease after a minimum of six months of follow-up, one reported spread to the cervical lymph nodes, and only one reported progression with distant metastasis.Conclusion:Oral mucosal melanoma in situ is a rare entity and most commonly treated with surgical excision. High rates of recurrence necessitate long term follow-up. Further studies may be useful to determine whether adjuvant therapy may play a role in reducing recurrence. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/mucosal-melanoma-n-situ-of-the-oral-cavity-a-case-/54930 mucosal melanoma in situoral cavityhard palatemanagementsystematic review |
| spellingShingle | Polly Jasper W. Nicholas Jungbauer Nicolas S. Poupore Shaun A. Nguyen Jim Howell Brad W. Neville Terry A. Day Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature Turkish Archives of Otorhinolaryngology mucosal melanoma in situ oral cavity hard palate management systematic review |
| title | Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature |
| title_full | Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature |
| title_fullStr | Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature |
| title_full_unstemmed | Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature |
| title_short | Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature |
| title_sort | mucosal melanoma in situ of the oral cavity a case report and systematic review of the literature |
| topic | mucosal melanoma in situ oral cavity hard palate management systematic review |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/mucosal-melanoma-n-situ-of-the-oral-cavity-a-case-/54930
|
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