Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I>
Scientific relevance. Laminariae thalli are a native herbal preparation used to prevent or treat multiple diseases. To achieve the optimal effect, this herbal preparation is usually taken for several weeks or months. The control of Laminariae thalli should extend beyond the element content in the he...
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| Format: | Article |
| Language: | Russian |
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NEICON ISP LLC
2023-09-01
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| Series: | Ведомости Научного центра экспертизы средств медицинского применения |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/534 |
| _version_ | 1797198993848008704 |
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| author | V. M. Shchukin E. A. Khorolskaya N. E. Kuz’mina I. P. Remezova |
| author_facet | V. M. Shchukin E. A. Khorolskaya N. E. Kuz’mina I. P. Remezova |
| author_sort | V. M. Shchukin |
| collection | DOAJ |
| description | Scientific relevance. Laminariae thalli are a native herbal preparation used to prevent or treat multiple diseases. To achieve the optimal effect, this herbal preparation is usually taken for several weeks or months. The control of Laminariae thalli should extend beyond the element content in the herbal drug limited by specifications; additionally, it is important to assess the health risks of ingesting heavy metals with the medicinal product during the exposure period.Aim. The study aimed to assess the carcinogenic and non-carcinogenic risks of consuming elemental contaminants with therapeutic doses of herbal medicinal products based on Laminariae thalli.Materials and methods. The study investigated the content of elemental contaminants (Al, As, Cd, Cr, Co, Cu, Fe, Hg, Mn, Mo, Ni, Se, Pb, Sr, V, and Zn) in Laminaria saccharina and Laminaria japonica. The content of inorganic arsenic was determined by solid-phase extraction using inductively coupled plasma mass spectrometry (ICP-MS).Results. When averaged at the 90th percentile level, the mean concentrations of the specified elements did not exceed the limits for seaweed and seagrass foods. The total hazard index from exposure to all analysed elements amounted to 0.173 at the median level and 0.616 at the 90th percentile level. The leading contributors to the total hazard index were As, Fe, Cd, and Sr. The individual carcinogenic risk (CR) values for the potential carcinogens (As, Cd, Pb, and Cr) fell within the range of 1×10-6<CR<1×10-4.Conclusions. If the elements analysed are ingested with a daily therapeutic dose of Laminariae thalli for the exposure period, their total negative effect will not cause harm to the human body. To eliminate the risk of developing neoplasms when the studied medicinal product (Laminariae thalli) is taken at its maximum recommended therapeutic dose for a month or more, the Cr content should be controlled along with the elements limited by specifications for herbal medicines. |
| first_indexed | 2024-03-07T19:17:11Z |
| format | Article |
| id | doaj.art-792fa7c0bff5497b89899336e34190e7 |
| institution | Directory Open Access Journal |
| issn | 1991-2919 2619-1172 |
| language | Russian |
| last_indexed | 2024-04-24T07:08:41Z |
| publishDate | 2023-09-01 |
| publisher | NEICON ISP LLC |
| record_format | Article |
| series | Ведомости Научного центра экспертизы средств медицинского применения |
| spelling | doaj.art-792fa7c0bff5497b89899336e34190e72024-04-21T11:46:35ZrusNEICON ISP LLCВедомости Научного центра экспертизы средств медицинского применения1991-29192619-11722023-09-0113343344110.30895/1991-2919-2023-534397Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I>V. M. Shchukin0E. A. Khorolskaya1N. E. Kuz’mina2I. P. Remezova3Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsPyatigorsk Medical and Pharmaceutical Institute, Branch of the Volgograd State Medical UniversityScientific relevance. Laminariae thalli are a native herbal preparation used to prevent or treat multiple diseases. To achieve the optimal effect, this herbal preparation is usually taken for several weeks or months. The control of Laminariae thalli should extend beyond the element content in the herbal drug limited by specifications; additionally, it is important to assess the health risks of ingesting heavy metals with the medicinal product during the exposure period.Aim. The study aimed to assess the carcinogenic and non-carcinogenic risks of consuming elemental contaminants with therapeutic doses of herbal medicinal products based on Laminariae thalli.Materials and methods. The study investigated the content of elemental contaminants (Al, As, Cd, Cr, Co, Cu, Fe, Hg, Mn, Mo, Ni, Se, Pb, Sr, V, and Zn) in Laminaria saccharina and Laminaria japonica. The content of inorganic arsenic was determined by solid-phase extraction using inductively coupled plasma mass spectrometry (ICP-MS).Results. When averaged at the 90th percentile level, the mean concentrations of the specified elements did not exceed the limits for seaweed and seagrass foods. The total hazard index from exposure to all analysed elements amounted to 0.173 at the median level and 0.616 at the 90th percentile level. The leading contributors to the total hazard index were As, Fe, Cd, and Sr. The individual carcinogenic risk (CR) values for the potential carcinogens (As, Cd, Pb, and Cr) fell within the range of 1×10-6<CR<1×10-4.Conclusions. If the elements analysed are ingested with a daily therapeutic dose of Laminariae thalli for the exposure period, their total negative effect will not cause harm to the human body. To eliminate the risk of developing neoplasms when the studied medicinal product (Laminariae thalli) is taken at its maximum recommended therapeutic dose for a month or more, the Cr content should be controlled along with the elements limited by specifications for herbal medicines.https://www.vedomostincesmp.ru/jour/article/view/534<i>laminaria saccharina</i><i>laminaria japonica</i><i>laminariae thalli</i>kelpelemental contaminantshazard quotienthazard indexindividual carcinogenic risk |
| spellingShingle | V. M. Shchukin E. A. Khorolskaya N. E. Kuz’mina I. P. Remezova Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> Ведомости Научного центра экспертизы средств медицинского применения <i>laminaria saccharina</i> <i>laminaria japonica</i> <i>laminariae thalli</i> kelp elemental contaminants hazard quotient hazard index individual carcinogenic risk |
| title | Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> |
| title_full | Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> |
| title_fullStr | Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> |
| title_full_unstemmed | Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> |
| title_short | Carcinogenic and Non-Carcinogenic Health Risks Assessment of Elemental Contaminants in <I>Laminariae thalli</I> |
| title_sort | carcinogenic and non carcinogenic health risks assessment of elemental contaminants in i laminariae thalli i |
| topic | <i>laminaria saccharina</i> <i>laminaria japonica</i> <i>laminariae thalli</i> kelp elemental contaminants hazard quotient hazard index individual carcinogenic risk |
| url | https://www.vedomostincesmp.ru/jour/article/view/534 |
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