Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment
In laboratory rats, a minimal arrhythmogenic dose of 1, 5 % KCl solution (15 mg/kg) was injected intravenously in 2 seconds. Hypopolarization arrhythmias were registered in 3-10 seconds, followed by regular sinus rhythm. In experimental groups, the animals received a minimal arrhythmogenic dose of K...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2006-06-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1842 |
| _version_ | 1797857223330758656 |
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| author | V. M. Moroz T. N. Lipnitsky |
| author_facet | V. M. Moroz T. N. Lipnitsky |
| author_sort | V. M. Moroz |
| collection | DOAJ |
| description | In laboratory rats, a minimal arrhythmogenic dose of 1, 5 % KCl solution (15 mg/kg) was injected intravenously in 2 seconds. Hypopolarization arrhythmias were registered in 3-10 seconds, followed by regular sinus rhythm. In experimental groups, the animals received a minimal arrhythmogenic dose of KCl in 5 minutes after intravenous infusion of 1 % novocainamidum (20 mg/kg) or 0, 25 % ethacyzin (4 mg/kg). In all 20 rats, N a+ cannel blocker and KCl bolus administration resulted in cardioplegy; in every second animal, asystolia and death were registered (40 % and 60 %, respectively). Therefore, in coronary heart disease patients, receiving Na+ channel blockers, sudden death pathogenesis might be influenced by membrane hyperpolarization, due to Na+/K+-ATPase dysfunction, low cytosol concentration of K+ ions, and their decreased flow from the cells in final repolarization phase. |
| first_indexed | 2024-04-09T20:54:19Z |
| format | Article |
| id | doaj.art-793233ef27d94f49a0a9a35c91f8de7c |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:54:19Z |
| publishDate | 2006-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-793233ef27d94f49a0a9a35c91f8de7c2023-03-29T21:23:13Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202006-06-010367701603Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatmentV. M. Moroz0T. N. Lipnitsky1Винницкий национальный медицинский университетВинницкий национальный медицинский университетIn laboratory rats, a minimal arrhythmogenic dose of 1, 5 % KCl solution (15 mg/kg) was injected intravenously in 2 seconds. Hypopolarization arrhythmias were registered in 3-10 seconds, followed by regular sinus rhythm. In experimental groups, the animals received a minimal arrhythmogenic dose of KCl in 5 minutes after intravenous infusion of 1 % novocainamidum (20 mg/kg) or 0, 25 % ethacyzin (4 mg/kg). In all 20 rats, N a+ cannel blocker and KCl bolus administration resulted in cardioplegy; in every second animal, asystolia and death were registered (40 % and 60 %, respectively). Therefore, in coronary heart disease patients, receiving Na+ channel blockers, sudden death pathogenesis might be influenced by membrane hyperpolarization, due to Na+/K+-ATPase dysfunction, low cytosol concentration of K+ ions, and their decreased flow from the cells in final repolarization phase.https://russjcardiol.elpub.ru/jour/article/view/1842sudden deathcardiac arrhythmiasmembrane hyperpolarizationhyperkaliemiaarrhythmogenic effects of antiarrhythmics |
| spellingShingle | V. M. Moroz T. N. Lipnitsky Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment Российский кардиологический журнал sudden death cardiac arrhythmias membrane hyperpolarization hyperkaliemia arrhythmogenic effects of antiarrhythmics |
| title | Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment |
| title_full | Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment |
| title_fullStr | Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment |
| title_full_unstemmed | Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment |
| title_short | Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment |
| title_sort | experimental modeling of sudden death pathological mechanisms in na channel blocker treatment |
| topic | sudden death cardiac arrhythmias membrane hyperpolarization hyperkaliemia arrhythmogenic effects of antiarrhythmics |
| url | https://russjcardiol.elpub.ru/jour/article/view/1842 |
| work_keys_str_mv | AT vmmoroz experimentalmodelingofsuddendeathpathologicalmechanismsinnachannelblockertreatment AT tnlipnitsky experimentalmodelingofsuddendeathpathologicalmechanismsinnachannelblockertreatment |