Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma
Objective To examine the safety and efficacy of concomitant chemoradiotherapy using a modified TPF regimen (docetaxel + cisplatin + 5-fluorouracil) in patients with advanced sinonasal squamous cell carcinoma (SNSCC). Study Design Retrospective study. Setting Tertiary center (university hospital). Me...
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | OTO Open |
| Online Access: | https://doi.org/10.1177/2473974X211045298 |
| _version_ | 1827614109374349312 |
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| author | Katsunori Katagiri MD, PhD Kiyoto Shiga MD, PhD Daisuke Saito MD Shin-ichi Oikawa MD, PhD Aya Ikeda MD, PhD Kodai Tsuchida MD, PhD Jun Miyaguchi MD, PhD Takahiro Kusaka MD Takumi Sariishi MD Hisanori Ariga MD, PhD |
| author_facet | Katsunori Katagiri MD, PhD Kiyoto Shiga MD, PhD Daisuke Saito MD Shin-ichi Oikawa MD, PhD Aya Ikeda MD, PhD Kodai Tsuchida MD, PhD Jun Miyaguchi MD, PhD Takahiro Kusaka MD Takumi Sariishi MD Hisanori Ariga MD, PhD |
| author_sort | Katsunori Katagiri MD, PhD |
| collection | DOAJ |
| description | Objective To examine the safety and efficacy of concomitant chemoradiotherapy using a modified TPF regimen (docetaxel + cisplatin + 5-fluorouracil) in patients with advanced sinonasal squamous cell carcinoma (SNSCC). Study Design Retrospective study. Setting Tertiary center (university hospital). Methods Seven patients with previously untreated T3-T4 SNSCC were enrolled. They underwent radiotherapy once daily (total dose, 70 Gy) with 2 courses of concomitant 120-hour infusion of 5-fluorouracil (600 mg/m 2 /d), docetaxel (50 mg/m 2 , day 2), and cisplatin (60 mg/m 2 , day 2) Results Grade 4 leukopenia, grade 4 neutropenia, and grade 3 lymphopenia were observed in 1, 3, and 4 patients, respectively. Grade 4 creatinine elevation was observed in 1 patient. However, other grade 3 or 4 adverse events were not common. Complete response was obtained in all patients. At 60 months there was 85.7% disease-free survival and 100% overall. Conclusion Concomitant chemoradiotherapy with a modified TPF regimen may be feasible and effective in patients with advanced SNSCC. |
| first_indexed | 2024-03-09T08:50:03Z |
| format | Article |
| id | doaj.art-79361f0247344feca028cd0c114e9783 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-03-09T08:50:03Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-79361f0247344feca028cd0c114e97832023-12-02T14:33:29ZengWileyOTO Open2473-974X2021-09-01510.1177/2473974X211045298Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell CarcinomaKatsunori Katagiri MD, PhD0Kiyoto Shiga MD, PhD1Daisuke Saito MD2Shin-ichi Oikawa MD, PhD3Aya Ikeda MD, PhD4Kodai Tsuchida MD, PhD5Jun Miyaguchi MD, PhD6Takahiro Kusaka MD7Takumi Sariishi MD8Hisanori Ariga MD, PhD9Department of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Head and Neck Surgery, Iwate Medical University Hospital, Yahaba-cho, JapanDepartment of Otolaryngology, Hachinohe City Hospital, Hachinohe, JapanDepartment of Radiology, Iwate Medical University Hospital, Yahaba-cho, JapanObjective To examine the safety and efficacy of concomitant chemoradiotherapy using a modified TPF regimen (docetaxel + cisplatin + 5-fluorouracil) in patients with advanced sinonasal squamous cell carcinoma (SNSCC). Study Design Retrospective study. Setting Tertiary center (university hospital). Methods Seven patients with previously untreated T3-T4 SNSCC were enrolled. They underwent radiotherapy once daily (total dose, 70 Gy) with 2 courses of concomitant 120-hour infusion of 5-fluorouracil (600 mg/m 2 /d), docetaxel (50 mg/m 2 , day 2), and cisplatin (60 mg/m 2 , day 2) Results Grade 4 leukopenia, grade 4 neutropenia, and grade 3 lymphopenia were observed in 1, 3, and 4 patients, respectively. Grade 4 creatinine elevation was observed in 1 patient. However, other grade 3 or 4 adverse events were not common. Complete response was obtained in all patients. At 60 months there was 85.7% disease-free survival and 100% overall. Conclusion Concomitant chemoradiotherapy with a modified TPF regimen may be feasible and effective in patients with advanced SNSCC.https://doi.org/10.1177/2473974X211045298 |
| spellingShingle | Katsunori Katagiri MD, PhD Kiyoto Shiga MD, PhD Daisuke Saito MD Shin-ichi Oikawa MD, PhD Aya Ikeda MD, PhD Kodai Tsuchida MD, PhD Jun Miyaguchi MD, PhD Takahiro Kusaka MD Takumi Sariishi MD Hisanori Ariga MD, PhD Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma OTO Open |
| title | Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma |
| title_full | Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma |
| title_fullStr | Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma |
| title_full_unstemmed | Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma |
| title_short | Preliminary Study of Chemoradiotherapy Using Modified Docetaxel, Cis-diaminodichloroplatinum, and 5-Fluorouracil for Sinonasal Squamous Cell Carcinoma |
| title_sort | preliminary study of chemoradiotherapy using modified docetaxel cis diaminodichloroplatinum and 5 fluorouracil for sinonasal squamous cell carcinoma |
| url | https://doi.org/10.1177/2473974X211045298 |
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