Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis
Several studies reported that the expression of SIRT1 was associated with the clinical features of patients with esophageal squamous cell carcinoma (ESCC), but the function remains inconsistent. We conducted this study to illustrate the clinical value of SIRT1 expression in the early diagnosis and p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-03-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2022-0454 |
| _version_ | 1811252821771681792 |
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| author | Zhang Yu-ling Chen Pei Guo Ying Zhang Yan-jun |
| author_facet | Zhang Yu-ling Chen Pei Guo Ying Zhang Yan-jun |
| author_sort | Zhang Yu-ling |
| collection | DOAJ |
| description | Several studies reported that the expression of SIRT1 was associated with the clinical features of patients with esophageal squamous cell carcinoma (ESCC), but the function remains inconsistent. We conducted this study to illustrate the clinical value of SIRT1 expression in the early diagnosis and prediction of prognosis of ESCC. In this study, PubMed, Embase, and Web of Science were searched by two independent researchers and STATA14.0 software was used to conduct meta-analysis. The odds ratio with 95% confidence interval was used to estimate the pooled effect. Egger’s test and Begg’s funnel were used to assess publication bias. Sensitivity analysis was used to evaluate the reliability and stability of meta-analysis results. According to the inclusion and exclusion criteria, six studies were enrolled, including 811 cases of ESCC. Results of the meta-analysis indicated that SIRT1 was overexpressed in ESCC and the SIRT1 expression was closely related to the clinicopathological features of ESCC, such as tumor infiltration, tumor node metastasis (TNM) stage, and lymph node metastasis. In the survival analysis, high expression of SIRT1 represented a poor prognosis in ESCC patients. Our study demonstrated that SIRT1 was overexpressed in ESCC, and it might be a potential biomarker for progress of ESCC. |
| first_indexed | 2024-04-12T16:40:32Z |
| format | Article |
| id | doaj.art-79367b0cab714167b417ebc0706ec172 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T16:40:32Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-79367b0cab714167b417ebc0706ec1722022-12-22T03:24:48ZengDe GruyterOpen Medicine2391-54632022-03-0117152753510.1515/med-2022-0454Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysisZhang Yu-ling0Chen Pei1Guo Ying2Zhang Yan-jun3Department of Public Health, Jiangsu College of Nursing, Huai’an, Jiangsu Province, ChinaDepartment of Basic Medicine, Jiangsu College of Nursing, Qing Jiang pu District, Huai’an, Jiangsu Province, 223005, ChinaDepartment of Medical Laboratory, Huai’an Maternal and Child Health Hospital, Jiangsu Province, ChinaDepartment of Basic Medicine, Jiangsu College of Nursing, Qing Jiang pu District, Huai’an, Jiangsu Province, 223005, ChinaSeveral studies reported that the expression of SIRT1 was associated with the clinical features of patients with esophageal squamous cell carcinoma (ESCC), but the function remains inconsistent. We conducted this study to illustrate the clinical value of SIRT1 expression in the early diagnosis and prediction of prognosis of ESCC. In this study, PubMed, Embase, and Web of Science were searched by two independent researchers and STATA14.0 software was used to conduct meta-analysis. The odds ratio with 95% confidence interval was used to estimate the pooled effect. Egger’s test and Begg’s funnel were used to assess publication bias. Sensitivity analysis was used to evaluate the reliability and stability of meta-analysis results. According to the inclusion and exclusion criteria, six studies were enrolled, including 811 cases of ESCC. Results of the meta-analysis indicated that SIRT1 was overexpressed in ESCC and the SIRT1 expression was closely related to the clinicopathological features of ESCC, such as tumor infiltration, tumor node metastasis (TNM) stage, and lymph node metastasis. In the survival analysis, high expression of SIRT1 represented a poor prognosis in ESCC patients. Our study demonstrated that SIRT1 was overexpressed in ESCC, and it might be a potential biomarker for progress of ESCC.https://doi.org/10.1515/med-2022-0454sirt1esccclinical featuresprogressionmeta-analysis |
| spellingShingle | Zhang Yu-ling Chen Pei Guo Ying Zhang Yan-jun Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis Open Medicine sirt1 escc clinical features progression meta-analysis |
| title | Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis |
| title_full | Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis |
| title_fullStr | Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis |
| title_full_unstemmed | Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis |
| title_short | Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis |
| title_sort | clinical value of sirt1 as a prognostic biomarker in esophageal squamous cell carcinoma a systematic meta analysis |
| topic | sirt1 escc clinical features progression meta-analysis |
| url | https://doi.org/10.1515/med-2022-0454 |
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