Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm syst...

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Bibliographic Details
Main Authors: Mary F Fontana, Simran Banga, Kevin C Barry, Xihui Shen, Yunhao Tan, Zhao-Qing Luo, Russell E Vance
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21390206/pdf/?tool=EBI

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