STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease
Subthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of Parkinson’s disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing β-synchronous oscillations between STN and the motor cortex with possible antikinetic features. However, STN-D...
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MDPI AG
2022-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/12/1606 |
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| author | Matteo Conti Alessandro Stefani Roberta Bovenzi Rocco Cerroni Elena Garasto Fabio Placidi Claudio Liguori Tommaso Schirinzi Nicola B. Mercuri Mariangela Pierantozzi |
| author_facet | Matteo Conti Alessandro Stefani Roberta Bovenzi Rocco Cerroni Elena Garasto Fabio Placidi Claudio Liguori Tommaso Schirinzi Nicola B. Mercuri Mariangela Pierantozzi |
| author_sort | Matteo Conti |
| collection | DOAJ |
| description | Subthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of Parkinson’s disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing β-synchronous oscillations between STN and the motor cortex with possible antikinetic features. However, STN-DBS modulation of β-band synchronization in extramotor cortical areas has been scarcely explored. For this aim, we investigated DBS-induced short-term effects on EEG-based cortical functional connectivity (FC) in β bands in six PD patients who underwent STN-DBS within the past year. A 10 min, 64-channel EEG recording was performed twice: in DBS-OFF and 60 min after DBS activation. Seven age-matched controls performed EEG recordings as the control group. A source-reconstruction method was used to identify brain-region activity. The FC was calculated using a weighted phase-lag index in β bands. Group comparisons were made using the Wilcoxon test. The PD patients showed a widespread cortical hyperconnectivity in β bands in both DBS-OFF and -ON states compared to the controls. Moreover, switching on STN-DBS determined an acute reduction in β FC, primarily involving corticocortical links of frontal, sensorimotor and limbic lobes. We hypothesize that an increase in β-band connectivity in PD is a widespread cortical phenomenon and that STN-DBS could quickly reduce it in the cortical regions primarily involved in basal ganglia–cortical circuits. |
| first_indexed | 2024-03-09T17:16:16Z |
| format | Article |
| id | doaj.art-793a1dbada7a4c6a81a99562e9fc953b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T17:16:16Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-793a1dbada7a4c6a81a99562e9fc953b2023-11-24T13:38:36ZengMDPI AGBrain Sciences2076-34252022-11-011212160610.3390/brainsci12121606STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s DiseaseMatteo Conti0Alessandro Stefani1Roberta Bovenzi2Rocco Cerroni3Elena Garasto4Fabio Placidi5Claudio Liguori6Tommaso Schirinzi7Nicola B. Mercuri8Mariangela Pierantozzi9Parkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyNeurology Unit, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyNeurology Unit, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyNeurology Unit, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyParkinson Centre, Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalySubthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of Parkinson’s disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing β-synchronous oscillations between STN and the motor cortex with possible antikinetic features. However, STN-DBS modulation of β-band synchronization in extramotor cortical areas has been scarcely explored. For this aim, we investigated DBS-induced short-term effects on EEG-based cortical functional connectivity (FC) in β bands in six PD patients who underwent STN-DBS within the past year. A 10 min, 64-channel EEG recording was performed twice: in DBS-OFF and 60 min after DBS activation. Seven age-matched controls performed EEG recordings as the control group. A source-reconstruction method was used to identify brain-region activity. The FC was calculated using a weighted phase-lag index in β bands. Group comparisons were made using the Wilcoxon test. The PD patients showed a widespread cortical hyperconnectivity in β bands in both DBS-OFF and -ON states compared to the controls. Moreover, switching on STN-DBS determined an acute reduction in β FC, primarily involving corticocortical links of frontal, sensorimotor and limbic lobes. We hypothesize that an increase in β-band connectivity in PD is a widespread cortical phenomenon and that STN-DBS could quickly reduce it in the cortical regions primarily involved in basal ganglia–cortical circuits.https://www.mdpi.com/2076-3425/12/12/1606Parkinson’s diseaseDBSEEG-based functional connectivity |
| spellingShingle | Matteo Conti Alessandro Stefani Roberta Bovenzi Rocco Cerroni Elena Garasto Fabio Placidi Claudio Liguori Tommaso Schirinzi Nicola B. Mercuri Mariangela Pierantozzi STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease Brain Sciences Parkinson’s disease DBS EEG-based functional connectivity |
| title | STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease |
| title_full | STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease |
| title_fullStr | STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease |
| title_full_unstemmed | STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease |
| title_short | STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson’s Disease |
| title_sort | stn dbs induces acute changes in β band cortical functional connectivity in patients with parkinson s disease |
| topic | Parkinson’s disease DBS EEG-based functional connectivity |
| url | https://www.mdpi.com/2076-3425/12/12/1606 |
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