Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ

Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ

Abstract The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of EV bulk biomarker characterization. Herein, we present a single‐EV and particle (siEVP) protein and RNA assay...

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Bibliographic Details
Main Authors: Jingjing Zhang, Xilal Y. Rima, Xinyu Wang, Luong T. H. Nguyen, Kristin Huntoon, Yifan Ma, Paola Loreto Palacio, Kim Truc Nguyen, Karunya Albert, Minh‐Dao Duong‐Thi, Nicole Walters, Kwang Joo Kwak, Min Jin Yoon, Hong Li, Jacob Doon‐Ralls, Colin L. Hisey, Daeyong Lee, Yifan Wang, Jonghoon Ha, Kelsey Scherler, Shannon Fallen, Inyoul Lee, Andre F. Palmer, Wen Jiang, Setty M. Magaña, Kai Wang, Betty Y. S. Kim, L. James Lee, Eduardo Reátegui
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Journal of Extracellular Vesicles
Subjects:
extracellular RNA
glioblastoma multiforme
heterogeneity
multiparametric
single extracellular vesicle
single lipoprotein
Online Access:https://doi.org/10.1002/jev2.12369

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