Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms?
This study aimed to evaluate the association of genetic variants in lactoferrin (<i>LTF</i>) metabolism-related genes with the prevalence of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). In total, 161 MHO and 291 MUHO subjects were recruited to the study...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2843 |
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| author | Małgorzata Jamka Nina Kaczmarek Edyta Mądry Patrycja Krzyżanowska-Jankowska Joanna Bajerska Matylda Kręgielska-Narożna Paweł Bogdański Jarosław Walkowiak |
| author_facet | Małgorzata Jamka Nina Kaczmarek Edyta Mądry Patrycja Krzyżanowska-Jankowska Joanna Bajerska Matylda Kręgielska-Narożna Paweł Bogdański Jarosław Walkowiak |
| author_sort | Małgorzata Jamka |
| collection | DOAJ |
| description | This study aimed to evaluate the association of genetic variants in lactoferrin (<i>LTF</i>) metabolism-related genes with the prevalence of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). In total, 161 MHO and 291 MUHO subjects were recruited to the study. The following polymorphisms were genotyped: low-density lipoprotein receptor-related protein (<i>LRP</i>) 2 rs2544390, <i>LRP1</i> rs4759277, <i>LRP1</i> rs1799986, <i>LTF</i> rs1126477, <i>LTF</i> rs2239692 and <i>LTF</i> rs1126478. We found significant differences in the genotype frequencies of <i>LTF</i> rs2239692 between MHO and MUHO subjects, with the CT variant associated with lower odds of developing metabolic syndrome than the TT variant. In the total population, significant differences in body weight and waist circumference (WC) were identified between <i>LTF</i> rs1126477 gene variants. A similar association with WC was observed in MUHO subjects, while significant differences in body mass index and low-density lipoprotein cholesterol levels were discovered between <i>LTF</i> rs1126477 gene variants in MHO subjects. Besides, there were significant differences in diastolic blood pressure between <i>LRP1</i> rs1799986 gene variants in MUHO subjects, as well as in WC and high-density lipoprotein cholesterol levels between <i>LRP1</i> rs4759277 gene variants in MHO subjects. In conclusion, selected lactoferrin and lactoferrin receptor-related gene variants may be associated with the prevalence of metabolically healthy or metabolically unhealthy obesity. |
| first_indexed | 2024-03-10T16:16:24Z |
| format | Article |
| id | doaj.art-793a929b4bc44924b24aec7051c66e46 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:16:24Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-793a929b4bc44924b24aec7051c66e462023-11-20T14:01:28ZengMDPI AGNutrients2072-66432020-09-01129284310.3390/nu12092843Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms?Małgorzata Jamka0Nina Kaczmarek1Edyta Mądry2Patrycja Krzyżanowska-Jankowska3Joanna Bajerska4Matylda Kręgielska-Narożna5Paweł Bogdański6Jarosław Walkowiak7Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, Święcickiego Str. 6, 60-781 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandInstitute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego Str. 31, 60-624 Poznań, PolandDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, 60-569 Poznań, PolandDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, 60-569 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandThis study aimed to evaluate the association of genetic variants in lactoferrin (<i>LTF</i>) metabolism-related genes with the prevalence of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). In total, 161 MHO and 291 MUHO subjects were recruited to the study. The following polymorphisms were genotyped: low-density lipoprotein receptor-related protein (<i>LRP</i>) 2 rs2544390, <i>LRP1</i> rs4759277, <i>LRP1</i> rs1799986, <i>LTF</i> rs1126477, <i>LTF</i> rs2239692 and <i>LTF</i> rs1126478. We found significant differences in the genotype frequencies of <i>LTF</i> rs2239692 between MHO and MUHO subjects, with the CT variant associated with lower odds of developing metabolic syndrome than the TT variant. In the total population, significant differences in body weight and waist circumference (WC) were identified between <i>LTF</i> rs1126477 gene variants. A similar association with WC was observed in MUHO subjects, while significant differences in body mass index and low-density lipoprotein cholesterol levels were discovered between <i>LTF</i> rs1126477 gene variants in MHO subjects. Besides, there were significant differences in diastolic blood pressure between <i>LRP1</i> rs1799986 gene variants in MUHO subjects, as well as in WC and high-density lipoprotein cholesterol levels between <i>LRP1</i> rs4759277 gene variants in MHO subjects. In conclusion, selected lactoferrin and lactoferrin receptor-related gene variants may be associated with the prevalence of metabolically healthy or metabolically unhealthy obesity.https://www.mdpi.com/2072-6643/12/9/2843lactoferrinlow-density lipoprotein receptor-related protein 1low-density lipoprotein receptor-related protein 2obesitysingle nucleotide polymorphism |
| spellingShingle | Małgorzata Jamka Nina Kaczmarek Edyta Mądry Patrycja Krzyżanowska-Jankowska Joanna Bajerska Matylda Kręgielska-Narożna Paweł Bogdański Jarosław Walkowiak Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? Nutrients lactoferrin low-density lipoprotein receptor-related protein 1 low-density lipoprotein receptor-related protein 2 obesity single nucleotide polymorphism |
| title | Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? |
| title_full | Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? |
| title_fullStr | Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? |
| title_full_unstemmed | Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? |
| title_short | Metabolic Health in Obese Subjects—Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? |
| title_sort | metabolic health in obese subjects is there a link to lactoferrin and lactoferrin receptor related gene polymorphisms |
| topic | lactoferrin low-density lipoprotein receptor-related protein 1 low-density lipoprotein receptor-related protein 2 obesity single nucleotide polymorphism |
| url | https://www.mdpi.com/2072-6643/12/9/2843 |
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