Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic hypoxia, inflammation, oxidative stress, and irreversible airflow limitations. Rhodiola L. is a genus of botanical drugs used in traditional medicine that may influence COPD.Objective: A systematic review of the saf...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1139239/full |
| _version_ | 1797851444862255104 |
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| author | Haichuan Yu Haichuan Yu Ting Lei Ting Lei Xiaojie Su Xiaojie Su Lu Zhang Lu Zhang Zhouzhou Feng Zhouzhou Feng Mengya Dong Zheyu Hou Hong Guo Hong Guo Jian Liu Jian Liu |
| author_facet | Haichuan Yu Haichuan Yu Ting Lei Ting Lei Xiaojie Su Xiaojie Su Lu Zhang Lu Zhang Zhouzhou Feng Zhouzhou Feng Mengya Dong Zheyu Hou Hong Guo Hong Guo Jian Liu Jian Liu |
| author_sort | Haichuan Yu |
| collection | DOAJ |
| description | Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic hypoxia, inflammation, oxidative stress, and irreversible airflow limitations. Rhodiola L. is a genus of botanical drugs used in traditional medicine that may influence COPD.Objective: A systematic review of the safety and efficacy of Rhodiola L. in patients with COPD.Material and methods: We searched the PubMed, Embase, Cochrane Library, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Chongqing VIP, Wanfang, and SinoMed databases. The search strategy used terms including “COPD” and “Rhodiola.” Two independent reviewers conducted the literature screening, data extraction, and risk of bias assessment, with a third reviewer involved to resolve disagreements. Statistical analysis was conducted in Review Manager (version 5.4.1), following the Cochrane Handbook.Results: This review included nine studies, of which two focused on Rhodiola crenulata (Hook.f. and Thomson) H. Ohba (R. crenulata) and two on Rhodiola kirilowii (Regel) Maxim (R. kirilowii); the remaining five focused on Rhodiola wallichiana (Hook.) S.H.Fu (R. wallichiana). Compared with the placebo, patients who received Rhodiola L. presented no more adverse events (p = 0.65) but showed significant improvement in the percentage of forced expiratory volume in 1 s at prediction (FEV1%pred), forced expiratory volume in 1 s (FEV1), the ratio of forced expiratory volume in 1 s on forced vital capacity (FEV1/FVC), saturation of oxygen in arterial blood, partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), systolic pulmonary arterial pressure, diastolic pulmonary arterial pressure, COPD assessment test, efficient rate, C-reactive protein, and N-terminal pro-B-type natriuretic peptide (all p < 0.01). Compared with ambroxol, R. kirilowii provided additional benefits to patients with COPD in FEV1%pred, FEV1, FEV1/FVC, PaO2, PaCO2, 8-iso-prostaglandin F2α, superoxide dismutase, glutathione, malondialdehyde, and total antioxidant capacity (all p < 0.01).Conclusion: Among the Rhodiola L. genus, this review included R. wallichiana, R. crenulata, and R. kirilowii, which might be safe and effective in COPD. Although this study has several limitations, further RCTs are needed.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/ display_record.php?RecordID=302881], identifier [CRD42022361890]. |
| first_indexed | 2024-04-09T19:16:53Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:16:53Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-793aef5639c040ecaa9a6fcd97e39ee32023-04-06T04:35:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11392391139239Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysisHaichuan Yu0Haichuan Yu1Ting Lei2Ting Lei3Xiaojie Su4Xiaojie Su5Lu Zhang6Lu Zhang7Zhouzhou Feng8Zhouzhou Feng9Mengya Dong10Zheyu Hou11Hong Guo12Hong Guo13Jian Liu14Jian Liu15Clinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaCritical Care Department, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Medicine Department, First Medical College, Lanzhou University, Lanzhou, ChinaSecretary’s Office, Gansu Province Maternity and Child Health Hospital, Gansu Province Central Hospital, Lanzhou, ChinaBackground: Chronic obstructive pulmonary disease (COPD) is characterized by chronic hypoxia, inflammation, oxidative stress, and irreversible airflow limitations. Rhodiola L. is a genus of botanical drugs used in traditional medicine that may influence COPD.Objective: A systematic review of the safety and efficacy of Rhodiola L. in patients with COPD.Material and methods: We searched the PubMed, Embase, Cochrane Library, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Chongqing VIP, Wanfang, and SinoMed databases. The search strategy used terms including “COPD” and “Rhodiola.” Two independent reviewers conducted the literature screening, data extraction, and risk of bias assessment, with a third reviewer involved to resolve disagreements. Statistical analysis was conducted in Review Manager (version 5.4.1), following the Cochrane Handbook.Results: This review included nine studies, of which two focused on Rhodiola crenulata (Hook.f. and Thomson) H. Ohba (R. crenulata) and two on Rhodiola kirilowii (Regel) Maxim (R. kirilowii); the remaining five focused on Rhodiola wallichiana (Hook.) S.H.Fu (R. wallichiana). Compared with the placebo, patients who received Rhodiola L. presented no more adverse events (p = 0.65) but showed significant improvement in the percentage of forced expiratory volume in 1 s at prediction (FEV1%pred), forced expiratory volume in 1 s (FEV1), the ratio of forced expiratory volume in 1 s on forced vital capacity (FEV1/FVC), saturation of oxygen in arterial blood, partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), systolic pulmonary arterial pressure, diastolic pulmonary arterial pressure, COPD assessment test, efficient rate, C-reactive protein, and N-terminal pro-B-type natriuretic peptide (all p < 0.01). Compared with ambroxol, R. kirilowii provided additional benefits to patients with COPD in FEV1%pred, FEV1, FEV1/FVC, PaO2, PaCO2, 8-iso-prostaglandin F2α, superoxide dismutase, glutathione, malondialdehyde, and total antioxidant capacity (all p < 0.01).Conclusion: Among the Rhodiola L. genus, this review included R. wallichiana, R. crenulata, and R. kirilowii, which might be safe and effective in COPD. Although this study has several limitations, further RCTs are needed.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/ display_record.php?RecordID=302881], identifier [CRD42022361890].https://www.frontiersin.org/articles/10.3389/fphar.2023.1139239/fullRhodiola L.chronic obstructive pulmonary diseasesafetyefficacysystematic review |
| spellingShingle | Haichuan Yu Haichuan Yu Ting Lei Ting Lei Xiaojie Su Xiaojie Su Lu Zhang Lu Zhang Zhouzhou Feng Zhouzhou Feng Mengya Dong Zheyu Hou Hong Guo Hong Guo Jian Liu Jian Liu Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis Frontiers in Pharmacology Rhodiola L. chronic obstructive pulmonary disease safety efficacy systematic review |
| title | Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| title_full | Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| title_short | Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
| title_sort | efficacy and safety of three species of rhodiola l in patients with chronic obstructive pulmonary disease a systematic review and meta analysis |
| topic | Rhodiola L. chronic obstructive pulmonary disease safety efficacy systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1139239/full |
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