More than just acral melanoma: the controversies of defining the disease
Abstract Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-11-01
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| Series: | The Journal of Pathology: Clinical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cjp2.233 |
| _version_ | 1818719072988168192 |
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| author | Sara S Bernardes Ingrid Ferreira David E Elder Aretha B Nobre Héctor Martínez‐Said David J Adams Carla Daniela Robles‐Espinoza Patricia A Possik |
| author_facet | Sara S Bernardes Ingrid Ferreira David E Elder Aretha B Nobre Héctor Martínez‐Said David J Adams Carla Daniela Robles‐Espinoza Patricia A Possik |
| author_sort | Sara S Bernardes |
| collection | DOAJ |
| description | Abstract Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease. |
| first_indexed | 2024-12-17T20:01:08Z |
| format | Article |
| id | doaj.art-793ce455d75d4c60a05e71f8bfa710c4 |
| institution | Directory Open Access Journal |
| issn | 2056-4538 |
| language | English |
| last_indexed | 2024-12-17T20:01:08Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Pathology: Clinical Research |
| spelling | doaj.art-793ce455d75d4c60a05e71f8bfa710c42022-12-21T21:34:28ZengWileyThe Journal of Pathology: Clinical Research2056-45382021-11-017653154110.1002/cjp2.233More than just acral melanoma: the controversies of defining the diseaseSara S Bernardes0Ingrid Ferreira1David E Elder2Aretha B Nobre3Héctor Martínez‐Said4David J Adams5Carla Daniela Robles‐Espinoza6Patricia A Possik7Program of Immunology and Tumour Biology Brazilian National Cancer Institute Rio de Janeiro BrazilExperimental Cancer Genetics Wellcome Sanger Institute Hinxton UKDivision of Anatomic Pathology Hospital of the University of Pennsylvania Philadelphia PA USADivision of Pathology Brazilian National Cancer Institute Rio de Janeiro BrazilServicio de Piel y Partes Blandas Instituto Nacional de Cancerología Ciudad de México MexicoExperimental Cancer Genetics Wellcome Sanger Institute Hinxton UKExperimental Cancer Genetics Wellcome Sanger Institute Hinxton UKProgram of Immunology and Tumour Biology Brazilian National Cancer Institute Rio de Janeiro BrazilAbstract Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease.https://doi.org/10.1002/cjp2.233acral melanomaepidemiologyhistopathologyprognosisgenetics |
| spellingShingle | Sara S Bernardes Ingrid Ferreira David E Elder Aretha B Nobre Héctor Martínez‐Said David J Adams Carla Daniela Robles‐Espinoza Patricia A Possik More than just acral melanoma: the controversies of defining the disease The Journal of Pathology: Clinical Research acral melanoma epidemiology histopathology prognosis genetics |
| title | More than just acral melanoma: the controversies of defining the disease |
| title_full | More than just acral melanoma: the controversies of defining the disease |
| title_fullStr | More than just acral melanoma: the controversies of defining the disease |
| title_full_unstemmed | More than just acral melanoma: the controversies of defining the disease |
| title_short | More than just acral melanoma: the controversies of defining the disease |
| title_sort | more than just acral melanoma the controversies of defining the disease |
| topic | acral melanoma epidemiology histopathology prognosis genetics |
| url | https://doi.org/10.1002/cjp2.233 |
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