Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
Abstract Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enuc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-09-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12348-021-00259-x |
| _version_ | 1819007661409042432 |
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| author | Amravi Shah Sneha Giridhar Gazal Patnaik Radhika Mhatre Dipankar Das M. K. Janani Anita Mahadevan Jyotirmay Biswas |
| author_facet | Amravi Shah Sneha Giridhar Gazal Patnaik Radhika Mhatre Dipankar Das M. K. Janani Anita Mahadevan Jyotirmay Biswas |
| author_sort | Amravi Shah |
| collection | DOAJ |
| description | Abstract Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings. |
| first_indexed | 2024-12-21T00:28:08Z |
| format | Article |
| id | doaj.art-793dc240071341129423c59a88c3dbdc |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-12-21T00:28:08Z |
| publishDate | 2021-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-793dc240071341129423c59a88c3dbdc2022-12-21T19:21:56ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602021-09-011111410.1186/s12348-021-00259-xHistopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ diseaseAmravi Shah0Sneha Giridhar1Gazal Patnaik2Radhika Mhatre3Dipankar Das4M. K. Janani5Anita Mahadevan6Jyotirmay Biswas7Uvea Department, Medical Research Foundation, Sankara NethralayaShri BhagwanMahavir Vitreoretinal Services Sankara NethralayaUvea Department, Medical Research Foundation, Sankara NethralayaDepartment of Neuropathology, NIMHANSDepartment of Uvea, Sri SankaradevaNethralayaSankara Nethralaya Referral LaboratoryDepartment of Neuropathology, NIMHANSUvea Department, Medical Research Foundation, Sankara NethralayaAbstract Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings.https://doi.org/10.1186/s12348-021-00259-xEales’ImmunohistochemistryPCRRetinalVasculitis |
| spellingShingle | Amravi Shah Sneha Giridhar Gazal Patnaik Radhika Mhatre Dipankar Das M. K. Janani Anita Mahadevan Jyotirmay Biswas Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease Journal of Ophthalmic Inflammation and Infection Eales’ Immunohistochemistry PCR Retinal Vasculitis |
| title | Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease |
| title_full | Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease |
| title_fullStr | Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease |
| title_full_unstemmed | Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease |
| title_short | Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease |
| title_sort | histopathological immunohistochemical and molecular biologic study of an enucleated specimen of a case of eales disease |
| topic | Eales’ Immunohistochemistry PCR Retinal Vasculitis |
| url | https://doi.org/10.1186/s12348-021-00259-x |
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