SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/73913 |