Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women
<p>Abstract</p> <p>Background</p> <p>Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influe...
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/9/112 |
| _version_ | 1818562090763288576 |
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| author | Amado José A García-Unzueta María T Zarrabeitia María T Valero Carmen Riancho José A González-Macías Jesús |
| author_facet | Amado José A García-Unzueta María T Zarrabeitia María T Valero Carmen Riancho José A González-Macías Jesús |
| author_sort | Amado José A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the <it>SHBG </it>gene on serum SHBG, bone mineral density (BMD), and osteoporotic fractures.</p> <p>Methods</p> <p>Four biallelic polymorphisms of the <it>SHBG </it>gene were studied by means of Taqman assays in 753 postmenopausal women. BMD was measured by DXA and serum SHBG was measured by ELISA.</p> <p>Results</p> <p>Age, body weight, and two polymorphisms of the <it>SHBG </it>gene (rs6257 and rs1799941 [A/G]) were significantly associated with serum SHBG in unadjusted and age- and weight-adjusted models. Alleles at the rs1799941 locus showed the strongest association with serum SHBG (p = 0.0004). The difference in SHBG levels between women with AA and GG genotypes at the rs1799941 locus was 39%. There were no significant differences in BMD across SHBG genotypes. The genotypes showed similar frequency distributions in control women and women with vertebral or hip fractures.</p> <p>Conclusion</p> <p>Some common genetic variants of the <it>SHBG </it>gene, and particularly an A/G polymorphism situated in the 5' region, influence serum SHBG levels. However, a significant association with BMD or osteoporotic fractures has not been demonstrated.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-14T00:59:09Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
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| series | BMC Medical Genetics |
| spelling | doaj.art-794052274c4641bb817e690e0e51ed4e2022-12-21T23:23:22ZengBMCBMC Medical Genetics1471-23502008-12-019111210.1186/1471-2350-9-112Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal womenAmado José AGarcía-Unzueta María TZarrabeitia María TValero CarmenRiancho José AGonzález-Macías Jesús<p>Abstract</p> <p>Background</p> <p>Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the <it>SHBG </it>gene on serum SHBG, bone mineral density (BMD), and osteoporotic fractures.</p> <p>Methods</p> <p>Four biallelic polymorphisms of the <it>SHBG </it>gene were studied by means of Taqman assays in 753 postmenopausal women. BMD was measured by DXA and serum SHBG was measured by ELISA.</p> <p>Results</p> <p>Age, body weight, and two polymorphisms of the <it>SHBG </it>gene (rs6257 and rs1799941 [A/G]) were significantly associated with serum SHBG in unadjusted and age- and weight-adjusted models. Alleles at the rs1799941 locus showed the strongest association with serum SHBG (p = 0.0004). The difference in SHBG levels between women with AA and GG genotypes at the rs1799941 locus was 39%. There were no significant differences in BMD across SHBG genotypes. The genotypes showed similar frequency distributions in control women and women with vertebral or hip fractures.</p> <p>Conclusion</p> <p>Some common genetic variants of the <it>SHBG </it>gene, and particularly an A/G polymorphism situated in the 5' region, influence serum SHBG levels. However, a significant association with BMD or osteoporotic fractures has not been demonstrated.</p>http://www.biomedcentral.com/1471-2350/9/112 |
| spellingShingle | Amado José A García-Unzueta María T Zarrabeitia María T Valero Carmen Riancho José A González-Macías Jesús Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women BMC Medical Genetics |
| title | Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| title_full | Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| title_fullStr | Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| title_full_unstemmed | Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| title_short | Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| title_sort | genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women |
| url | http://www.biomedcentral.com/1471-2350/9/112 |
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