Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different...
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MDPI AG
2020-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/1/176 |
| _version_ | 1797706794007527424 |
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| author | Sergio Quesada-Vázquez Gerard Aragonès Josep M Del Bas Xavier Escoté |
| author_facet | Sergio Quesada-Vázquez Gerard Aragonès Josep M Del Bas Xavier Escoté |
| author_sort | Sergio Quesada-Vázquez |
| collection | DOAJ |
| description | Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression. |
| first_indexed | 2024-03-12T05:57:33Z |
| format | Article |
| id | doaj.art-7941b2e045a949f887665cd7b7789a1d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T05:57:33Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7941b2e045a949f887665cd7b7789a1d2023-09-03T04:26:33ZengMDPI AGCells2073-44092020-01-019117610.3390/cells9010176cells9010176Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same AxisSergio Quesada-Vázquez0Gerard Aragonès1Josep M Del Bas2Xavier Escoté3Unitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, SpainDepartment of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Nutrigenomics Research Group, 43007 Tarragona, SpainUnitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, SpainUnitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, SpainNon-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression.https://www.mdpi.com/2073-4409/9/1/176non-alcohol fatty liver diseasegut microbiotanaflddysbiosisbacterial translocation |
| spellingShingle | Sergio Quesada-Vázquez Gerard Aragonès Josep M Del Bas Xavier Escoté Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis Cells non-alcohol fatty liver disease gut microbiota nafld dysbiosis bacterial translocation |
| title | Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis |
| title_full | Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis |
| title_fullStr | Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis |
| title_full_unstemmed | Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis |
| title_short | Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis |
| title_sort | diet gut microbiota and non alcoholic fatty liver disease three parts of the same axis |
| topic | non-alcohol fatty liver disease gut microbiota nafld dysbiosis bacterial translocation |
| url | https://www.mdpi.com/2073-4409/9/1/176 |
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