Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis
Background Hypospadias is one of the most common genital birth defects. There are around 300 various techniques available for the repair of hypospadias. This study aims to compare the reported outcomes of Tubularized incised plate urethroplasty (TIP) and Grafted TIP (GTIP) repair in children undergo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-01-01
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| Series: | World Journal of Pediatric Surgery |
| Online Access: | https://wjps.bmj.com/content/7/1/e000707.full |
| _version_ | 1797229115127889920 |
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| author | Abhijit Nair C K Sinha Nitinkumar Borkar Charu Tiwari Debajyoti Mohanty Jai Kumar Mahajan |
| author_facet | Abhijit Nair C K Sinha Nitinkumar Borkar Charu Tiwari Debajyoti Mohanty Jai Kumar Mahajan |
| author_sort | Abhijit Nair |
| collection | DOAJ |
| description | Background Hypospadias is one of the most common genital birth defects. There are around 300 various techniques available for the repair of hypospadias. This study aims to compare the reported outcomes of Tubularized incised plate urethroplasty (TIP) and Grafted TIP (GTIP) repair in children undergoing primary hypospadias repair.Methods This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and we framed our research question using the population, intervention, control and outcomes format. We conducted comprehensive electronic searches across various databases, employing a Boolean search strategy with predefined search terms. Only randomized controlled trials (RCTs) were included for quantitative analysis.Results Totally, 10 RCTs met our inclusion criteria for quantitative analysis. The results indicated that urethrocutaneous fistula, glans dehiscence, and stricture rates were comparable between the two groups. The incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk (RR) of 0.32 (95% confidence interval (CI) 0.15 to 0.67).Conclusion The coucomes UCF, glans dehiscence, and stricture rates were comparable between the two groups. Notably, the incidence of meatal stenosis was found to be significantly lower in the grafted TIP group. In terms of operative time, our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity. |
| first_indexed | 2024-03-07T23:04:14Z |
| format | Article |
| id | doaj.art-794574f367394bc29a3c6d4b34c9f156 |
| institution | Directory Open Access Journal |
| issn | 2516-5410 |
| language | English |
| last_indexed | 2024-04-24T15:07:27Z |
| publishDate | 2024-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | World Journal of Pediatric Surgery |
| spelling | doaj.art-794574f367394bc29a3c6d4b34c9f1562024-04-02T12:25:12ZengBMJ Publishing GroupWorld Journal of Pediatric Surgery2516-54102024-01-017110.1136/wjps-2023-000707Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysisAbhijit Nair0C K Sinha1Nitinkumar Borkar2Charu Tiwari3Debajyoti Mohanty4Jai Kumar Mahajan5Department of Anaesthesiology, Ibra Hospital, Ibra, OmanPaediatric Surgery, St George`s University Hospitals NHS Foundation Trust, London, UKPaediatric Surgery, All India Institute of Medical Sciences-Raipur, Raipur, Chhattisgardh, IndiaPaediatric Surgery, All India Institute of Medical Sciences-Raipur, Raipur, Chhattisgardh, IndiaGeneral Surgery, All India Institute of Medical Sciences-Raipur, Raipur, Chhattisgardh, IndiaPediatric Surgery, PGIMER, Chandigarh, IndiaBackground Hypospadias is one of the most common genital birth defects. There are around 300 various techniques available for the repair of hypospadias. This study aims to compare the reported outcomes of Tubularized incised plate urethroplasty (TIP) and Grafted TIP (GTIP) repair in children undergoing primary hypospadias repair.Methods This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and we framed our research question using the population, intervention, control and outcomes format. We conducted comprehensive electronic searches across various databases, employing a Boolean search strategy with predefined search terms. Only randomized controlled trials (RCTs) were included for quantitative analysis.Results Totally, 10 RCTs met our inclusion criteria for quantitative analysis. The results indicated that urethrocutaneous fistula, glans dehiscence, and stricture rates were comparable between the two groups. The incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk (RR) of 0.32 (95% confidence interval (CI) 0.15 to 0.67).Conclusion The coucomes UCF, glans dehiscence, and stricture rates were comparable between the two groups. Notably, the incidence of meatal stenosis was found to be significantly lower in the grafted TIP group. In terms of operative time, our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.https://wjps.bmj.com/content/7/1/e000707.full |
| spellingShingle | Abhijit Nair C K Sinha Nitinkumar Borkar Charu Tiwari Debajyoti Mohanty Jai Kumar Mahajan Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis World Journal of Pediatric Surgery |
| title | Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis |
| title_full | Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis |
| title_fullStr | Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis |
| title_full_unstemmed | Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis |
| title_short | Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis |
| title_sort | tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty systematic review meta analysis and trial sequential analysis |
| url | https://wjps.bmj.com/content/7/1/e000707.full |
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