A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF), activate transcription in response to all t...

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Bibliographic Details
Main Authors: Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A. R. Bluyssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
interferon
JAK/signal transducer and activator of transcription signaling pathway
signal transducer and activator of transcriptions
interferon-stimulated gene factor 3
interferon regulatory factor 1
transcriptional regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01135/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01135/full

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