Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study.
<h4>Purpose</h4>The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population....
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Format: | Article |
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Public Library of Science (PLoS)
2022-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0269550 |
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author | Tien Van Nguyen Kokichi Arisawa Sakurako Katsuura-Kamano Masashi Ishizu Mako Nagayoshi Rieko Okada Asahi Hishida Takashi Tamura Megumi Hara Keitaro Tanaka Daisaku Nishimoto Keiichi Shibuya Teruhide Koyama Isao Watanabe Sadao Suzuki Takeshi Nishiyama Kiyonori Kuriki Yasuyuki Nakamura Yoshino Saito Hiroaki Ikezaki Jun Otonari Yuriko N Koyanagi Keitaro Matsuo Haruo Mikami Miho Kusakabe Kenji Takeuchi Kenji Wakai |
author_facet | Tien Van Nguyen Kokichi Arisawa Sakurako Katsuura-Kamano Masashi Ishizu Mako Nagayoshi Rieko Okada Asahi Hishida Takashi Tamura Megumi Hara Keitaro Tanaka Daisaku Nishimoto Keiichi Shibuya Teruhide Koyama Isao Watanabe Sadao Suzuki Takeshi Nishiyama Kiyonori Kuriki Yasuyuki Nakamura Yoshino Saito Hiroaki Ikezaki Jun Otonari Yuriko N Koyanagi Keitaro Matsuo Haruo Mikami Miho Kusakabe Kenji Takeuchi Kenji Wakai |
author_sort | Tien Van Nguyen |
collection | DOAJ |
description | <h4>Purpose</h4>The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.<h4>Methods</h4>We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.<h4>Results</h4>During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).<h4>Conclusion</h4>MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population. |
first_indexed | 2024-04-13T03:16:32Z |
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institution | Directory Open Access Journal |
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language | English |
last_indexed | 2024-04-13T03:16:32Z |
publishDate | 2022-01-01 |
publisher | Public Library of Science (PLoS) |
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spelling | doaj.art-7946f2d1530c4912ac3814532b7e6d602022-12-22T03:04:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e026955010.1371/journal.pone.0269550Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study.Tien Van NguyenKokichi ArisawaSakurako Katsuura-KamanoMasashi IshizuMako NagayoshiRieko OkadaAsahi HishidaTakashi TamuraMegumi HaraKeitaro TanakaDaisaku NishimotoKeiichi ShibuyaTeruhide KoyamaIsao WatanabeSadao SuzukiTakeshi NishiyamaKiyonori KurikiYasuyuki NakamuraYoshino SaitoHiroaki IkezakiJun OtonariYuriko N KoyanagiKeitaro MatsuoHaruo MikamiMiho KusakabeKenji TakeuchiKenji Wakai<h4>Purpose</h4>The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.<h4>Methods</h4>We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.<h4>Results</h4>During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).<h4>Conclusion</h4>MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.https://doi.org/10.1371/journal.pone.0269550 |
spellingShingle | Tien Van Nguyen Kokichi Arisawa Sakurako Katsuura-Kamano Masashi Ishizu Mako Nagayoshi Rieko Okada Asahi Hishida Takashi Tamura Megumi Hara Keitaro Tanaka Daisaku Nishimoto Keiichi Shibuya Teruhide Koyama Isao Watanabe Sadao Suzuki Takeshi Nishiyama Kiyonori Kuriki Yasuyuki Nakamura Yoshino Saito Hiroaki Ikezaki Jun Otonari Yuriko N Koyanagi Keitaro Matsuo Haruo Mikami Miho Kusakabe Kenji Takeuchi Kenji Wakai Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. PLoS ONE |
title | Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. |
title_full | Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. |
title_fullStr | Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. |
title_full_unstemmed | Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. |
title_short | Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. |
title_sort | associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality the japan multi institutional collaborative cohort j micc study |
url | https://doi.org/10.1371/journal.pone.0269550 |
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