Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study
<i>Helicobacter pylori</i> infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of <i>H. pylori</i> infections....
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13997 |
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| author | Tae Ho Lee Hang Yeon Jeong Do Yeon An Haesung Kim Jeong-Yong Cho Do Young Hwang Hyoung Jae Lee Kyung-Sik Ham Jae-Hak Moon |
| author_facet | Tae Ho Lee Hang Yeon Jeong Do Yeon An Haesung Kim Jeong-Yong Cho Do Young Hwang Hyoung Jae Lee Kyung-Sik Ham Jae-Hak Moon |
| author_sort | Tae Ho Lee |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of <i>H. pylori</i> infections. However, antibiotic resistance in <i>H. pylori</i> is an emerging issue. Bamboo salt, a traditional Korean salt made by baking solar sea salt in bamboo barrels, can ameliorate the symptoms of various gastrointestinal diseases. Herein, we compared the anti-<i>H. pylori</i> activity of triple therapy (clarithromycin, metronidazole, and omeprazole), solar salt, and bamboo salt in vivo as a preliminary study. Four-week-old C57BL/6 male mice were inoculated for eight weeks with the <i>H. pylori</i> Sydney Strain 1 (SS-1) and orally administered triple therapy drugs and salts for five days. The transcript levels of the <i>H. pylori</i>-expressed gene <i>CagA</i> and inflammatory cytokines <i>Tnfα</i> and <i>Il-1β</i> significantly decreased in the bamboo salt treated mice than those in the <i>H. pylori</i>-infected control group. This effect was further enhanced by using triple therapy and bamboo salt together. Solar salt caused modest inhibition of <i>H. pylori</i>-induced inflammation. We also demonstrated the synergistic effects of bamboo salt and triple therapy against <i>H. pylori</i>. Thus, bamboo salt may be a potential candidate agent against the treatment of <i>H. pylori</i>-associated gastritis. |
| first_indexed | 2024-03-09T18:17:43Z |
| format | Article |
| id | doaj.art-7946fcadc74c457dbdd2edd8dd2f84c5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:17:43Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7946fcadc74c457dbdd2edd8dd2f84c52023-11-24T08:36:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221399710.3390/ijms232213997Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary StudyTae Ho Lee0Hang Yeon Jeong1Do Yeon An2Haesung Kim3Jeong-Yong Cho4Do Young Hwang5Hyoung Jae Lee6Kyung-Sik Ham7Jae-Hak Moon8Department of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Biotechnology, Mokpo National University, Mokpo 58554, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of KoreaDepartment of Food Biotechnology, Mokpo National University, Mokpo 58554, Republic of KoreaDepartment of Food Science and Technology, Chonnam National University, 77 Yongbongro, Gwangju 61186, Republic of Korea<i>Helicobacter pylori</i> infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of <i>H. pylori</i> infections. However, antibiotic resistance in <i>H. pylori</i> is an emerging issue. Bamboo salt, a traditional Korean salt made by baking solar sea salt in bamboo barrels, can ameliorate the symptoms of various gastrointestinal diseases. Herein, we compared the anti-<i>H. pylori</i> activity of triple therapy (clarithromycin, metronidazole, and omeprazole), solar salt, and bamboo salt in vivo as a preliminary study. Four-week-old C57BL/6 male mice were inoculated for eight weeks with the <i>H. pylori</i> Sydney Strain 1 (SS-1) and orally administered triple therapy drugs and salts for five days. The transcript levels of the <i>H. pylori</i>-expressed gene <i>CagA</i> and inflammatory cytokines <i>Tnfα</i> and <i>Il-1β</i> significantly decreased in the bamboo salt treated mice than those in the <i>H. pylori</i>-infected control group. This effect was further enhanced by using triple therapy and bamboo salt together. Solar salt caused modest inhibition of <i>H. pylori</i>-induced inflammation. We also demonstrated the synergistic effects of bamboo salt and triple therapy against <i>H. pylori</i>. Thus, bamboo salt may be a potential candidate agent against the treatment of <i>H. pylori</i>-associated gastritis.https://www.mdpi.com/1422-0067/23/22/13997<i>Helicobacter pylori</i>bamboo salttriple therapyantimicrobialgastritisanti-inflammatory |
| spellingShingle | Tae Ho Lee Hang Yeon Jeong Do Yeon An Haesung Kim Jeong-Yong Cho Do Young Hwang Hyoung Jae Lee Kyung-Sik Ham Jae-Hak Moon Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study International Journal of Molecular Sciences <i>Helicobacter pylori</i> bamboo salt triple therapy antimicrobial gastritis anti-inflammatory |
| title | Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study |
| title_full | Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study |
| title_fullStr | Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study |
| title_full_unstemmed | Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study |
| title_short | Bamboo Salt and Triple Therapy Synergistically Inhibit <i>Helicobacter pylori</i>-Induced Gastritis In Vivo: A Preliminary Study |
| title_sort | bamboo salt and triple therapy synergistically inhibit i helicobacter pylori i induced gastritis in vivo a preliminary study |
| topic | <i>Helicobacter pylori</i> bamboo salt triple therapy antimicrobial gastritis anti-inflammatory |
| url | https://www.mdpi.com/1422-0067/23/22/13997 |
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