Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women
Abstract We tested whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, associates with insulin resistance, β-cell function and postglucose glycemia. We studied 311 young and 148 middle-aged Japanese women, whose BMI averaged < 23.0 kg/m2. Insulinoge...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-35001-1 |
| _version_ | 1797822878719148032 |
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| author | Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Mari Honda Mika Takeuchi Kaori Kitaoka Miki Kurata Bin Wu Tsutomu Kazumi Keisuke Fukuo |
| author_facet | Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Mari Honda Mika Takeuchi Kaori Kitaoka Miki Kurata Bin Wu Tsutomu Kazumi Keisuke Fukuo |
| author_sort | Satomi Minato-Inokawa |
| collection | DOAJ |
| description | Abstract We tested whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, associates with insulin resistance, β-cell function and postglucose glycemia. We studied 311 young and 148 middle-aged Japanese women, whose BMI averaged < 23.0 kg/m2. Insulinogenic index and Matsuda index were evaluated in 110 young and 65 middle-aged women. In two groups of women, ALT/AST was associated positively with homeostasis model assessment insulin resistance (HOMA-IR) and inversely with Matsuda index. In middle-aged women only, the ratio was also associated positively with fasting and postload glycemia and HbA1c. The ratio showed negative association with disposition index (a product of insulinogenic index and Matsuda index). On multivariate linear regression analysis, HOMA-IR emerged as a single determinant of ALT/AST in young and middle-aged women (standardized β: 0.209, p = 0.003 and 0.372, p = 0.002, respectively). ALT/AST was associated with insulin resistance and β-cell function even in non-obese Japanese women, suggesting a pathophysiologic basis in its prediction of diabetic risk. |
| first_indexed | 2024-03-13T10:15:49Z |
| format | Article |
| id | doaj.art-7948fbacea9149a59be5ead451e8f178 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T10:15:49Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7948fbacea9149a59be5ead451e8f1782023-05-21T11:16:22ZengNature PortfolioScientific Reports2045-23222023-05-011311710.1038/s41598-023-35001-1Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in womenSatomi Minato-Inokawa0Ayaka Tsuboi-Kaji1Mari Honda2Mika Takeuchi3Kaori Kitaoka4Miki Kurata5Bin Wu6Tsutomu Kazumi7Keisuke Fukuo8Research Institute for Nutrition Sciences, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityOpen Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityOpen Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityResearch Institute for Nutrition Sciences, Mukogawa Women’s UniversityAbstract We tested whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, associates with insulin resistance, β-cell function and postglucose glycemia. We studied 311 young and 148 middle-aged Japanese women, whose BMI averaged < 23.0 kg/m2. Insulinogenic index and Matsuda index were evaluated in 110 young and 65 middle-aged women. In two groups of women, ALT/AST was associated positively with homeostasis model assessment insulin resistance (HOMA-IR) and inversely with Matsuda index. In middle-aged women only, the ratio was also associated positively with fasting and postload glycemia and HbA1c. The ratio showed negative association with disposition index (a product of insulinogenic index and Matsuda index). On multivariate linear regression analysis, HOMA-IR emerged as a single determinant of ALT/AST in young and middle-aged women (standardized β: 0.209, p = 0.003 and 0.372, p = 0.002, respectively). ALT/AST was associated with insulin resistance and β-cell function even in non-obese Japanese women, suggesting a pathophysiologic basis in its prediction of diabetic risk.https://doi.org/10.1038/s41598-023-35001-1 |
| spellingShingle | Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Mari Honda Mika Takeuchi Kaori Kitaoka Miki Kurata Bin Wu Tsutomu Kazumi Keisuke Fukuo Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women Scientific Reports |
| title | Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women |
| title_full | Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women |
| title_fullStr | Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women |
| title_full_unstemmed | Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women |
| title_short | Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women |
| title_sort | associations of alanine aminotransferase aspartate aminotransferase with insulin resistance and β cell function in women |
| url | https://doi.org/10.1038/s41598-023-35001-1 |
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