Advances and Prospects in Vaccine Development against Enterococci
Enterococci are the second most common Gram-positive pathogen responsible for nosocomial infections. Due to the limited number of new antibiotics that reach the medical practice and the resistance of enterococci to the current antibiotic options, passive and active immunotherapies have emerged as a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2397 |
| _version_ | 1797549046908321792 |
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| author | Ermioni Kalfopoulou Johannes Huebner |
| author_facet | Ermioni Kalfopoulou Johannes Huebner |
| author_sort | Ermioni Kalfopoulou |
| collection | DOAJ |
| description | Enterococci are the second most common Gram-positive pathogen responsible for nosocomial infections. Due to the limited number of new antibiotics that reach the medical practice and the resistance of enterococci to the current antibiotic options, passive and active immunotherapies have emerged as a potential prevention and/or treatment strategy against this opportunistic pathogen. In this review, we explore the pathogenicity of these bacteria and their interaction with the host immune response. We provide an overview of the capsular polysaccharides and surface-associated proteins that have been described as potential antigens in anti-enterococcal vaccine formulations. In addition, we describe the current status in vaccine development against enterococci and address the importance and the current advances toward the development of well-defined vaccines with broad coverage against enterococci. |
| first_indexed | 2024-03-10T15:09:07Z |
| format | Article |
| id | doaj.art-794a60ecde2f42fabbfe41005342c21b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:09:07Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-794a60ecde2f42fabbfe41005342c21b2023-11-20T19:29:29ZengMDPI AGCells2073-44092020-11-01911239710.3390/cells9112397Advances and Prospects in Vaccine Development against EnterococciErmioni Kalfopoulou0Johannes Huebner1Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, GermanyDivision of Paediatric Infectious Diseases, Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, 80337 Munich, GermanyEnterococci are the second most common Gram-positive pathogen responsible for nosocomial infections. Due to the limited number of new antibiotics that reach the medical practice and the resistance of enterococci to the current antibiotic options, passive and active immunotherapies have emerged as a potential prevention and/or treatment strategy against this opportunistic pathogen. In this review, we explore the pathogenicity of these bacteria and their interaction with the host immune response. We provide an overview of the capsular polysaccharides and surface-associated proteins that have been described as potential antigens in anti-enterococcal vaccine formulations. In addition, we describe the current status in vaccine development against enterococci and address the importance and the current advances toward the development of well-defined vaccines with broad coverage against enterococci.https://www.mdpi.com/2073-4409/9/11/2397enterococci<i>Enterococcus faecalis</i><i>Enterococcus faecium</i>VREvancomycin-resistant enterococcivaccine |
| spellingShingle | Ermioni Kalfopoulou Johannes Huebner Advances and Prospects in Vaccine Development against Enterococci Cells enterococci <i>Enterococcus faecalis</i> <i>Enterococcus faecium</i> VRE vancomycin-resistant enterococci vaccine |
| title | Advances and Prospects in Vaccine Development against Enterococci |
| title_full | Advances and Prospects in Vaccine Development against Enterococci |
| title_fullStr | Advances and Prospects in Vaccine Development against Enterococci |
| title_full_unstemmed | Advances and Prospects in Vaccine Development against Enterococci |
| title_short | Advances and Prospects in Vaccine Development against Enterococci |
| title_sort | advances and prospects in vaccine development against enterococci |
| topic | enterococci <i>Enterococcus faecalis</i> <i>Enterococcus faecium</i> VRE vancomycin-resistant enterococci vaccine |
| url | https://www.mdpi.com/2073-4409/9/11/2397 |
| work_keys_str_mv | AT ermionikalfopoulou advancesandprospectsinvaccinedevelopmentagainstenterococci AT johanneshuebner advancesandprospectsinvaccinedevelopmentagainstenterococci |