Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients
Neurosyphilis is a serious global health issue and a big challenge in developing countries, related risk factors should be taken seriously. Although there are a certain number of studies describing the clinical and laboratory features and risk factors for symptomatic neurosyphilis (SNS), but some ri...
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| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024040428 |
| _version_ | 1797224133852921856 |
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| author | Wei Li Jinfang Sun Tingting Wang Yiyuan Liu Weifang Zhou Xiaoyong Man |
| author_facet | Wei Li Jinfang Sun Tingting Wang Yiyuan Liu Weifang Zhou Xiaoyong Man |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Neurosyphilis is a serious global health issue and a big challenge in developing countries, related risk factors should be taken seriously. Although there are a certain number of studies describing the clinical and laboratory features and risk factors for symptomatic neurosyphilis (SNS), but some risk factors are still controversial. The aim of this research is to investigate the association between asymptomatic neurosyphilis (ANS) and symptomatic neurosyphilis (SNS) and identify risk factors for SNS. This was a single-center retrospective study in a tertiary hospital in Hangzhou, China. The clinical and laboratory features of neurosyphilis patients from January 1, 2011 to July 31, 2020 were retrospectively reviewed. After detailed assessments based on diagnostic criteria, 402 patients with neurosyphilis were enrolled in this study. There were 299 male and 103 female patients. The median age was 53.5 (45, 61) years. Multivariable logistic regression displayed that SNS were correlated with the following factors: male, without anti-syphilis treatment, high pretreatment serum RPR titer and positive CSF RPR. Our findings suggest a potential association between SNS and specific factors, including male gender, elevated pretreatment serum and CSF RPR titers. Moreover, our observations indicate that individuals without anti-syphilis treatment may be at a higher likelihood of manifesting the symptomatic form. This underscores the importance of considering gender, RPR titers, and treatment status as significant contributors to the risk profile for SNS. |
| first_indexed | 2024-04-24T13:48:17Z |
| format | Article |
| id | doaj.art-794a90af745940378af033657285eb96 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:48:17Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-794a90af745940378af033657285eb962024-04-04T05:06:37ZengElsevierHeliyon2405-84402024-03-01106e28011Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patientsWei Li0Jinfang Sun1Tingting Wang2Yiyuan Liu3Weifang Zhou4Xiaoyong Man5Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Corresponding author.Neurosyphilis is a serious global health issue and a big challenge in developing countries, related risk factors should be taken seriously. Although there are a certain number of studies describing the clinical and laboratory features and risk factors for symptomatic neurosyphilis (SNS), but some risk factors are still controversial. The aim of this research is to investigate the association between asymptomatic neurosyphilis (ANS) and symptomatic neurosyphilis (SNS) and identify risk factors for SNS. This was a single-center retrospective study in a tertiary hospital in Hangzhou, China. The clinical and laboratory features of neurosyphilis patients from January 1, 2011 to July 31, 2020 were retrospectively reviewed. After detailed assessments based on diagnostic criteria, 402 patients with neurosyphilis were enrolled in this study. There were 299 male and 103 female patients. The median age was 53.5 (45, 61) years. Multivariable logistic regression displayed that SNS were correlated with the following factors: male, without anti-syphilis treatment, high pretreatment serum RPR titer and positive CSF RPR. Our findings suggest a potential association between SNS and specific factors, including male gender, elevated pretreatment serum and CSF RPR titers. Moreover, our observations indicate that individuals without anti-syphilis treatment may be at a higher likelihood of manifesting the symptomatic form. This underscores the importance of considering gender, RPR titers, and treatment status as significant contributors to the risk profile for SNS.http://www.sciencedirect.com/science/article/pii/S2405844024040428NeurosyphilisSymptomatic neurosyphilisAsymptomatic neurosyphilisRisk factorsRetrospective study |
| spellingShingle | Wei Li Jinfang Sun Tingting Wang Yiyuan Liu Weifang Zhou Xiaoyong Man Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients Heliyon Neurosyphilis Symptomatic neurosyphilis Asymptomatic neurosyphilis Risk factors Retrospective study |
| title | Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients |
| title_full | Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients |
| title_fullStr | Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients |
| title_full_unstemmed | Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients |
| title_short | Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients |
| title_sort | clinical and laboratory features of neurosyphilis a single center retrospective study of 402 patients |
| topic | Neurosyphilis Symptomatic neurosyphilis Asymptomatic neurosyphilis Risk factors Retrospective study |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024040428 |
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