A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
Catabolizing lignin-derived aromatic compounds requires an aryl-O-demethylation step. Here the authors present the structures of GcoA and GcoB, a cytochrome P450-reductase pair that catalyzes aryl-O-demethylations and show that GcoA displays broad substrate specificity, which is of interest for biot...
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Bibliographic Details
| Main Authors: |
Sam J. B. Mallinson,
Melodie M. Machovina,
Rodrigo L. Silveira,
Marc Garcia-Borràs,
Nathan Gallup,
Christopher W. Johnson,
Mark D. Allen,
Munir S. Skaf,
Michael F. Crowley,
Ellen L. Neidle,
Kendall N. Houk,
Gregg T. Beckham,
Jennifer L. DuBois,
John E. McGeehan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04878-2
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