Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels
Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2572 |
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| author | Raminta Vaiciuleviciute Daiva Bironaite Ilona Uzieliene Ali Mobasheri Eiva Bernotiene |
| author_facet | Raminta Vaiciuleviciute Daiva Bironaite Ilona Uzieliene Ali Mobasheri Eiva Bernotiene |
| author_sort | Raminta Vaiciuleviciute |
| collection | DOAJ |
| description | Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, β-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols. |
| first_indexed | 2024-03-10T06:39:34Z |
| format | Article |
| id | doaj.art-794c161ae3134815ba5f47b451f7479b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:34Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-794c161ae3134815ba5f47b451f7479b2023-11-22T17:45:46ZengMDPI AGCells2073-44092021-09-011010257210.3390/cells10102572Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion ChannelsRaminta Vaiciuleviciute0Daiva Bironaite1Ilona Uzieliene2Ali Mobasheri3Eiva Bernotiene4Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaOsteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, β-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols.https://www.mdpi.com/2073-4409/10/10/2572osteoarthritiscardiovascular drugshypertensionvascular dysfunctioncartilagechondrocyte |
| spellingShingle | Raminta Vaiciuleviciute Daiva Bironaite Ilona Uzieliene Ali Mobasheri Eiva Bernotiene Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels Cells osteoarthritis cardiovascular drugs hypertension vascular dysfunction cartilage chondrocyte |
| title | Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels |
| title_full | Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels |
| title_fullStr | Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels |
| title_full_unstemmed | Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels |
| title_short | Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels |
| title_sort | cardiovascular drugs and osteoarthritis effects of targeting ion channels |
| topic | osteoarthritis cardiovascular drugs hypertension vascular dysfunction cartilage chondrocyte |
| url | https://www.mdpi.com/2073-4409/10/10/2572 |
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