Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance
Abstract Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should be anti‐coagulantion, anti‐proliferation and promoting endothelialisation. Nitric oxide (NO), as a physiological gas signalling molecule, play an important role in reva...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Biosurface and Biotribology |
| Subjects: | |
| Online Access: | https://doi.org/10.1049/bsb2.12060 |
| _version_ | 1797810264975867904 |
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| author | Zhiyong Li Lu Zhang Lei Zhou Xin Li Yuancong Zhao Jin Wang |
| author_facet | Zhiyong Li Lu Zhang Lei Zhou Xin Li Yuancong Zhao Jin Wang |
| author_sort | Zhiyong Li |
| collection | DOAJ |
| description | Abstract Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should be anti‐coagulantion, anti‐proliferation and promoting endothelialisation. Nitric oxide (NO), as a physiological gas signalling molecule, play an important role in revascularisation. Catalysing the release of NO from endogenous donors has already been widely favoured to treatment strategy for lesioned vessels. In this work, a series of copper‐loaded coatings (titanium nanotube (TNT)/PDA‐Cu) was fabricated by TNTs combined with polydopamine and ions, which achieve controlled in situ catalytic release of NO. This strategy could effectively immobilised copper ions on TNTs, and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells (SMCs) via the performance of NO, as well as restrain the platelet adhesion. With the multiple function, TNT/PDA‐Cu provides a promise approach for promoting endothelialisation, anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs. |
| first_indexed | 2024-03-13T07:06:38Z |
| format | Article |
| id | doaj.art-794c4ca543fa4942a52ddb86bfaaf12b |
| institution | Directory Open Access Journal |
| issn | 2405-4518 |
| language | English |
| last_indexed | 2024-03-13T07:06:38Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biosurface and Biotribology |
| spelling | doaj.art-794c4ca543fa4942a52ddb86bfaaf12b2023-06-06T10:24:55ZengWileyBiosurface and Biotribology2405-45182023-06-0192455710.1049/bsb2.12060Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performanceZhiyong Li0Lu Zhang1Lei Zhou2Xin Li3Yuancong Zhao4Jin Wang5Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaInstitute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaInstitute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaInstitute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaInstitute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaInstitute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan ChinaAbstract Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should be anti‐coagulantion, anti‐proliferation and promoting endothelialisation. Nitric oxide (NO), as a physiological gas signalling molecule, play an important role in revascularisation. Catalysing the release of NO from endogenous donors has already been widely favoured to treatment strategy for lesioned vessels. In this work, a series of copper‐loaded coatings (titanium nanotube (TNT)/PDA‐Cu) was fabricated by TNTs combined with polydopamine and ions, which achieve controlled in situ catalytic release of NO. This strategy could effectively immobilised copper ions on TNTs, and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells (SMCs) via the performance of NO, as well as restrain the platelet adhesion. With the multiple function, TNT/PDA‐Cu provides a promise approach for promoting endothelialisation, anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs.https://doi.org/10.1049/bsb2.12060copper ionsin‐situ releasenitric oxidetitanium nanotubes |
| spellingShingle | Zhiyong Li Lu Zhang Lei Zhou Xin Li Yuancong Zhao Jin Wang Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance Biosurface and Biotribology copper ions in‐situ release nitric oxide titanium nanotubes |
| title | Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance |
| title_full | Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance |
| title_fullStr | Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance |
| title_full_unstemmed | Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance |
| title_short | Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance |
| title_sort | tunable catalytic release of nitric oxide via copper loaded coatings on titanium nanotubes for regulating biological performance |
| topic | copper ions in‐situ release nitric oxide titanium nanotubes |
| url | https://doi.org/10.1049/bsb2.12060 |
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