Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.

Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.

The glycosphingolipid isoglobotrihexosylceramide, or isogloboside 3 (iGb3), is believed to be critical for natural killer T (NKT) cell development and self-recognition in mice and humans. Furthermore, iGb3 may represent an important obstacle in xenotransplantation, in which this lipid represents the...

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Bibliographic Details
Main Authors: Dale Christiansen, Julie Milland, Effie Mouhtouris, Hilary Vaughan, Daniel G Pellicci, Malcolm J McConville, Dale I Godfrey, Mauro S Sandrin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18630988/pdf/?tool=EBI

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