Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo

Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo

Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells. We have recently shown that in mice precursors of cDCs, but not of other leukocytes, are marked by expression of DNGR-1/CLEC9A. To gene...

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Bibliographic Details
Main Authors: Johanna Salvermoser, Janneke van Blijswijk, Nikos E. Papaioannou, Stephan Rambichler, Maria Pasztoi, Dalia Pakalniškytė, Neil C. Rogers, Selina J. Keppler, Tobias Straub, Caetano Reis e Sousa, Barbara U. Schraml
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
development
CLEC9A/DNGR-1
DC depletion
myelopoiesis
lymphopoiesis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00699/full

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