FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES
To prepare ethosomes containing tea tree oil by hot homogenization method and to evaluate its physical characters and in-vitro release pattern. the preformulation studies were carried out by standard procedure. The morphology of globule was studied by optical microscopy. The globule size and zeta p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2016-01-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1033 |
| _version_ | 1819013468689268736 |
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| author | Vijayan Venugopal Raymond Goh Tan Yee Ping Tan Jia Jin |
| author_facet | Vijayan Venugopal Raymond Goh Tan Yee Ping Tan Jia Jin |
| author_sort | Vijayan Venugopal |
| collection | DOAJ |
| description | To prepare ethosomes containing tea tree oil by hot homogenization method and to evaluate its physical characters and in-vitro release pattern. the preformulation studies were carried out by standard procedure. The morphology of globule was studied by optical microscopy. The globule size and zeta potential was determined by Zetasizer, respectively and in-vitro study was done by diffusion method and the drug content was analyzed by HPTLC method. The release kinetics was also studied by fitting into few mathematical models. All the formulations were showed spherical and unilamellar shape with globule size of 931 to 975 nm, the zeta potential in the range of – 40 to -52 mV and entrapment efficiency was 57 to 65 %. Finally the invitro release studies showed the drug release from the ethosomal vesicles was burst release at initial time followed by sustained release over throughout the study. From the above consideration of evaluation studies, the tea tree oil loaded ethosomal formulation F5 shows best globule size, zeta potential and entrapment efficiency. The sustained action was confirmed by invitro release studies. All the formulations are followed zero order drug release and diffusion type of mechanism of drug releases with Fickian model. Ethosome loaded tea tree oil could be the best choice for topical application. |
| first_indexed | 2024-12-21T02:00:26Z |
| format | Article |
| id | doaj.art-795010d2f8ae4fa2aa3397276669540a |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-21T02:00:26Z |
| publishDate | 2016-01-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-795010d2f8ae4fa2aa3397276669540a2022-12-21T19:19:39ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862016-01-012714452http://dx.doi.org/10.14499/indonesianjpharm27iss1pp44FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMESVijayan Venugopal0Raymond Goh1Tan Yee Ping2Tan Jia Jin3Faculty of Pharmacy, AIMST University, Kedah, Semeling, Malaysia-08100.Faculty of Pharmacy, AIMST University, Kedah, Semeling, Malaysia-08100.Faculty of Pharmacy, AIMST University, Kedah, Semeling, Malaysia-08100.Faculty of Pharmacy, AIMST University, Kedah, Semeling, Malaysia-08100.To prepare ethosomes containing tea tree oil by hot homogenization method and to evaluate its physical characters and in-vitro release pattern. the preformulation studies were carried out by standard procedure. The morphology of globule was studied by optical microscopy. The globule size and zeta potential was determined by Zetasizer, respectively and in-vitro study was done by diffusion method and the drug content was analyzed by HPTLC method. The release kinetics was also studied by fitting into few mathematical models. All the formulations were showed spherical and unilamellar shape with globule size of 931 to 975 nm, the zeta potential in the range of – 40 to -52 mV and entrapment efficiency was 57 to 65 %. Finally the invitro release studies showed the drug release from the ethosomal vesicles was burst release at initial time followed by sustained release over throughout the study. From the above consideration of evaluation studies, the tea tree oil loaded ethosomal formulation F5 shows best globule size, zeta potential and entrapment efficiency. The sustained action was confirmed by invitro release studies. All the formulations are followed zero order drug release and diffusion type of mechanism of drug releases with Fickian model. Ethosome loaded tea tree oil could be the best choice for topical application.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1033Tea Tree OilEthosomesHPTLCGlobule SizeZeta Potential |
| spellingShingle | Vijayan Venugopal Raymond Goh Tan Yee Ping Tan Jia Jin FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES Indonesian Journal of Pharmacy Tea Tree Oil Ethosomes HPTLC Globule Size Zeta Potential |
| title | FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES |
| title_full | FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES |
| title_fullStr | FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES |
| title_full_unstemmed | FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES |
| title_short | FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES |
| title_sort | formulation development and characterization of tea tree oil loaded ethosomes |
| topic | Tea Tree Oil Ethosomes HPTLC Globule Size Zeta Potential |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1033 |
| work_keys_str_mv | AT vijayanvenugopal formulationdevelopmentandcharacterizationofteatreeoilloadedethosomes AT raymondgoh formulationdevelopmentandcharacterizationofteatreeoilloadedethosomes AT tanyeeping formulationdevelopmentandcharacterizationofteatreeoilloadedethosomes AT tanjiajin formulationdevelopmentandcharacterizationofteatreeoilloadedethosomes |