Advances in COVID-19 mRNA vaccine development
Abstract To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 deaths worldwide. COVID-19 is a serious threat to human health globally. The World Health Organization (WHO) has declared CO...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-03-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-00950-y |
| _version_ | 1811332203022385152 |
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| author | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li |
| author_facet | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li |
| author_sort | Enyue Fang |
| collection | DOAJ |
| description | Abstract To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 deaths worldwide. COVID-19 is a serious threat to human health globally. The World Health Organization (WHO) has declared COVID-19 pandemic a major public health emergency. Vaccination is the most effective and economical intervention for controlling the spread of epidemics, and consequently saving lives and protecting the health of the population. Various techniques have been employed in the development of COVID-19 vaccines. Among these, the COVID-19 messenger RNA (mRNA) vaccine has been drawing increasing attention owing to its great application prospects and advantages, which include short development cycle, easy industrialization, simple production process, flexibility to respond to new variants, and the capacity to induce better immune response. This review summarizes current knowledge on the structural characteristics, antigen design strategies, delivery systems, industrialization potential, quality control, latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology. Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. |
| first_indexed | 2024-04-13T16:32:29Z |
| format | Article |
| id | doaj.art-795278d0da6e40e39ec9d1e93a4b810d |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-13T16:32:29Z |
| publishDate | 2022-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-795278d0da6e40e39ec9d1e93a4b810d2022-12-22T02:39:31ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-03-017113110.1038/s41392-022-00950-yAdvances in COVID-19 mRNA vaccine developmentEnyue Fang0Xiaohui Liu1Miao Li2Zelun Zhang3Lifang Song4Baiyu Zhu5Xiaohong Wu6Jingjing Liu7Danhua Zhao8Yuhua Li9National Institute for Food and Drug ControlNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlTexas A&M UniversityNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlNational Institute for Food and Drug ControlAbstract To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 deaths worldwide. COVID-19 is a serious threat to human health globally. The World Health Organization (WHO) has declared COVID-19 pandemic a major public health emergency. Vaccination is the most effective and economical intervention for controlling the spread of epidemics, and consequently saving lives and protecting the health of the population. Various techniques have been employed in the development of COVID-19 vaccines. Among these, the COVID-19 messenger RNA (mRNA) vaccine has been drawing increasing attention owing to its great application prospects and advantages, which include short development cycle, easy industrialization, simple production process, flexibility to respond to new variants, and the capacity to induce better immune response. This review summarizes current knowledge on the structural characteristics, antigen design strategies, delivery systems, industrialization potential, quality control, latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology. Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed.https://doi.org/10.1038/s41392-022-00950-y |
| spellingShingle | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li Advances in COVID-19 mRNA vaccine development Signal Transduction and Targeted Therapy |
| title | Advances in COVID-19 mRNA vaccine development |
| title_full | Advances in COVID-19 mRNA vaccine development |
| title_fullStr | Advances in COVID-19 mRNA vaccine development |
| title_full_unstemmed | Advances in COVID-19 mRNA vaccine development |
| title_short | Advances in COVID-19 mRNA vaccine development |
| title_sort | advances in covid 19 mrna vaccine development |
| url | https://doi.org/10.1038/s41392-022-00950-y |
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