Taxifolin Prevents Cisplatin Nephrotoxicity by Modulating Nrf2/HO-1 Pathway and Mitigating Oxidative Stress and Inflammation in Mice

Taxifolin Prevents Cisplatin Nephrotoxicity by Modulating Nrf2/HO-1 Pathway and Mitigating Oxidative Stress and Inflammation in Mice

Cisplatin (CIS) is an effective chemotherapeutic agent used in the treatment of several malignancies. The clinical use of CIS is associated with adverse effects, including acute kidney injury (AKI). Oxidative stress and inflammation are key events in the development of CIS-induced AKI. This study in...

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Bibliographic Details
Main Authors: Abdulkareem A. Alanezi, Afaf F. Almuqati, Manal A. Alfwuaires, Fawaz Alasmari, Nader I. Namazi, Osama Y. Althunibat, Ayman M. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
kidney injury
chemotherapy
flavonoids
Nrf2
oxidative stress
Online Access:https://www.mdpi.com/1424-8247/15/11/1310

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