Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis
Mucormycosis is an invasive opportunistic fungal infection, which may be lethal and mostly affects patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. is the most common cause of mucormycosis, followed by genera such as Mucor and Lichtheimia. Here we report a pa...
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Elsevier
2024-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024018711 |
| _version_ | 1827322308850614272 |
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| author | Lihan Hai Peihong Li Zheng Xiao Jinxia Zhou Bo Xiao Luo Zhou |
| author_facet | Lihan Hai Peihong Li Zheng Xiao Jinxia Zhou Bo Xiao Luo Zhou |
| author_sort | Lihan Hai |
| collection | DOAJ |
| description | Mucormycosis is an invasive opportunistic fungal infection, which may be lethal and mostly affects patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. is the most common cause of mucormycosis, followed by genera such as Mucor and Lichtheimia. Here we report a patient with severe COVID-19 infection who developed nasal pain, facial swelling, prominent black eschar on the nasal root. CT scan revealed pansinusitis along the maxillary, ethmoidal, and sphenoid sinuses. Mixed mold infection with Rhizopus microsporus and Mucor racemosus was detected by blood metagenomics next-generation sequencing (mNGS) and later nasal mucosa histological investigation confirmed mucormycosis. Severe COVID-19 infection led to the patient's thrombocytopenia and leukopenia. Later disseminated mucormycosis aggravated the infection and sepsis eventually resulted in death.It is the first case report of mucormycosis in which R. microsporus and M. racemosus as the etiologic agents were found simultaneously in one patient. COVID-19 infection combined with disseminated mucormycosisis can be fatal and mNGS is a fast, sensitive and accurate diagnostic method for fungi detection. |
| first_indexed | 2024-03-08T03:29:24Z |
| format | Article |
| id | doaj.art-7959ee255075408e99f6d3ba6ca84f6f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:21:26Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7959ee255075408e99f6d3ba6ca84f6f2024-03-09T09:26:19ZengElsevierHeliyon2405-84402024-02-01104e25840Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosisLihan Hai0Peihong Li1Zheng Xiao2Jinxia Zhou3Bo Xiao4Luo Zhou5Department of Neurology, Xing'an League People's Hospital, Ulanhot, Inner Mongolia, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Pathology, First Hospital of Changsha, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Medical Research Center for Geriatric Diseases (Xiangya Hospital), Central South University, Changsha, Hunan, China; Corresponding author. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Mucormycosis is an invasive opportunistic fungal infection, which may be lethal and mostly affects patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. is the most common cause of mucormycosis, followed by genera such as Mucor and Lichtheimia. Here we report a patient with severe COVID-19 infection who developed nasal pain, facial swelling, prominent black eschar on the nasal root. CT scan revealed pansinusitis along the maxillary, ethmoidal, and sphenoid sinuses. Mixed mold infection with Rhizopus microsporus and Mucor racemosus was detected by blood metagenomics next-generation sequencing (mNGS) and later nasal mucosa histological investigation confirmed mucormycosis. Severe COVID-19 infection led to the patient's thrombocytopenia and leukopenia. Later disseminated mucormycosis aggravated the infection and sepsis eventually resulted in death.It is the first case report of mucormycosis in which R. microsporus and M. racemosus as the etiologic agents were found simultaneously in one patient. COVID-19 infection combined with disseminated mucormycosisis can be fatal and mNGS is a fast, sensitive and accurate diagnostic method for fungi detection.http://www.sciencedirect.com/science/article/pii/S2405844024018711MucormycosismNGSRhizopus microsporusMucor racemosussSevere COVID-19 |
| spellingShingle | Lihan Hai Peihong Li Zheng Xiao Jinxia Zhou Bo Xiao Luo Zhou Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis Heliyon Mucormycosis mNGS Rhizopus microsporus Mucor racemosuss Severe COVID-19 |
| title | Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis |
| title_full | Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis |
| title_fullStr | Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis |
| title_full_unstemmed | Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis |
| title_short | Rhizopus microsporus and Mucor racemosus coinfection following COVID-19 detected by metagenomics next-generation sequencing: A case of disseminated mucormycosis |
| title_sort | rhizopus microsporus and mucor racemosus coinfection following covid 19 detected by metagenomics next generation sequencing a case of disseminated mucormycosis |
| topic | Mucormycosis mNGS Rhizopus microsporus Mucor racemosuss Severe COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024018711 |
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