The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels
Bone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ult...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1765 |
| _version_ | 1797506518925443072 |
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| author | Jae Seo Lee Hyo-Sung Kim Haram Nah Sang Jin Lee Ho-Jin Moon Jae Beum Bang Jung Bok Lee Sun Hee Do Il Keun Kwon Dong Nyoung Heo |
| author_facet | Jae Seo Lee Hyo-Sung Kim Haram Nah Sang Jin Lee Ho-Jin Moon Jae Beum Bang Jung Bok Lee Sun Hee Do Il Keun Kwon Dong Nyoung Heo |
| author_sort | Jae Seo Lee |
| collection | DOAJ |
| description | Bone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ultimately leads to it migrating away from the defect after transplantation. We tested chitosan hydrogels as a useful carrier to hold BGMs in the transplantation area. In this study, we synthesized succinylated chitosan (SCS)-based hydrogels with a high decomposition rate and excellent biocompatibility. We confirmed that BGMs were well distributed inside the SCS hydrogel. The SCS-B hydrogel showed a decrease in mechanical properties, such as compressive strength and Young’s modulus, as the succinylation rate increased. SCS-B hydrogels also exhibited a high cell growth rate and bone differentiation rate. Moreover, the in vivo results showed that the SCS hydrogel resorbed into the surrounding tissues while maintaining the BGMs in the transplantation area for up to 6 weeks. These data support the idea that SCS hydrogel can be useful as a bioactive drug carrier for a broad range of biomedical applications. |
| first_indexed | 2024-03-10T04:33:47Z |
| format | Article |
| id | doaj.art-795affad5892403c893e5abd90ba5baf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:47Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-795affad5892403c893e5abd90ba5baf2023-11-23T03:55:12ZengMDPI AGBiomedicines2227-90592021-11-01912176510.3390/biomedicines9121765The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan HydrogelsJae Seo Lee0Hyo-Sung Kim1Haram Nah2Sang Jin Lee3Ho-Jin Moon4Jae Beum Bang5Jung Bok Lee6Sun Hee Do7Il Keun Kwon8Dong Nyoung Heo9Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, KoreaDepartment of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Dental Education, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemum-gu, Seoul 02447, KoreaDepartment of Biological Science, Sookmyung Women’s University, Cheongpa-ro 47-gil 100 (Cheongpa-dong 2(i)-ga), Yongsan-gu, Seoul 04310, KoreaDepartment of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, KoreaDepartment of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaBone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ultimately leads to it migrating away from the defect after transplantation. We tested chitosan hydrogels as a useful carrier to hold BGMs in the transplantation area. In this study, we synthesized succinylated chitosan (SCS)-based hydrogels with a high decomposition rate and excellent biocompatibility. We confirmed that BGMs were well distributed inside the SCS hydrogel. The SCS-B hydrogel showed a decrease in mechanical properties, such as compressive strength and Young’s modulus, as the succinylation rate increased. SCS-B hydrogels also exhibited a high cell growth rate and bone differentiation rate. Moreover, the in vivo results showed that the SCS hydrogel resorbed into the surrounding tissues while maintaining the BGMs in the transplantation area for up to 6 weeks. These data support the idea that SCS hydrogel can be useful as a bioactive drug carrier for a broad range of biomedical applications.https://www.mdpi.com/2227-9059/9/12/1765natural polymer-based hydrogelchitosanbone graftsuccinylationbone tissue engineering |
| spellingShingle | Jae Seo Lee Hyo-Sung Kim Haram Nah Sang Jin Lee Ho-Jin Moon Jae Beum Bang Jung Bok Lee Sun Hee Do Il Keun Kwon Dong Nyoung Heo The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels Biomedicines natural polymer-based hydrogel chitosan bone graft succinylation bone tissue engineering |
| title | The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels |
| title_full | The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels |
| title_fullStr | The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels |
| title_full_unstemmed | The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels |
| title_short | The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels |
| title_sort | effectiveness of compartmentalized bone graft sponges made using complementary bone graft materials and succinylated chitosan hydrogels |
| topic | natural polymer-based hydrogel chitosan bone graft succinylation bone tissue engineering |
| url | https://www.mdpi.com/2227-9059/9/12/1765 |
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