atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current ge...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2022-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article |
| _version_ | 1818027438935900160 |
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| author | Laure Fournier Le Ray Alexandra Aubry Wladimir Sougakoff Matthieu Revest Jérôme Robert Isabelle Bonnet Nicolas Veziris Florence Morel |
| author_facet | Laure Fournier Le Ray Alexandra Aubry Wladimir Sougakoff Matthieu Revest Jérôme Robert Isabelle Bonnet Nicolas Veziris Florence Morel |
| author_sort | Laure Fournier Le Ray |
| collection | DOAJ |
| description |
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
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| first_indexed | 2024-12-10T04:47:55Z |
| format | Article |
| id | doaj.art-795d6d8be0af4bb5abb4c410ac8ab404 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T04:47:55Z |
| publishDate | 2022-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-795d6d8be0af4bb5abb4c410ac8ab4042022-12-22T02:01:41ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-05-012851062106410.3201/eid2805.212517atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment FailureLaure Fournier Le RayAlexandra AubryWladimir SougakoffMatthieu RevestJérôme RobertIsabelle BonnetNicolas VezirisFlorence Morel We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance. https://wwwnc.cdc.gov/eid/article/28/5/21-2517_articletuberculosisatpEbedaquilineMDR TBXDR TBRv0678 |
| spellingShingle | Laure Fournier Le Ray Alexandra Aubry Wladimir Sougakoff Matthieu Revest Jérôme Robert Isabelle Bonnet Nicolas Veziris Florence Morel atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure Emerging Infectious Diseases tuberculosis atpE bedaquiline MDR TB XDR TB Rv0678 |
| title | atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure |
| title_full | atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure |
| title_fullStr | atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure |
| title_full_unstemmed | atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure |
| title_short | atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure |
| title_sort | atpe mutation in mycobacterium tuberculosis not always predictive of bedaquiline treatment failure |
| topic | tuberculosis atpE bedaquiline MDR TB XDR TB Rv0678 |
| url | https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article |
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