atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current ge...

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Bibliographic Details
Main Authors: Laure Fournier Le Ray, Alexandra Aubry, Wladimir Sougakoff, Matthieu Revest, Jérôme Robert, Isabelle Bonnet, Nicolas Veziris, Florence Morel
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2022-05-01
Series:Emerging Infectious Diseases
Subjects:
tuberculosis
atpE
bedaquiline
MDR TB
XDR TB
Rv0678
Online Access:https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article

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