Gli Proteins: Regulation in Development and Cancer
Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttran...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/2/147 |
| _version_ | 1797713626290716672 |
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| author | Paweł Niewiadomski Sylwia M. Niedziółka Łukasz Markiewicz Tomasz Uśpieński Brygida Baran Katarzyna Chojnowska |
| author_facet | Paweł Niewiadomski Sylwia M. Niedziółka Łukasz Markiewicz Tomasz Uśpieński Brygida Baran Katarzyna Chojnowska |
| author_sort | Paweł Niewiadomski |
| collection | DOAJ |
| description | Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttranslational modifications and intracellular transport. We also discuss how Gli proteins interact with co-activators and co-repressors to fine-tune the expression of Hedgehog target genes. Finally, we provide an overview of the regulation of developmental processes and tissue regeneration by Gli proteins and discuss how these proteins are involved in cancer progression, both through canonical regulation via the Hedgehog pathway and through cross-talk with other signaling pathways. |
| first_indexed | 2024-03-12T07:39:29Z |
| format | Article |
| id | doaj.art-795fdaf4b8f940fe9c800b6aadf842c0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:39:29Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-795fdaf4b8f940fe9c800b6aadf842c02023-09-02T21:22:55ZengMDPI AGCells2073-44092019-02-018214710.3390/cells8020147cells8020147Gli Proteins: Regulation in Development and CancerPaweł Niewiadomski0Sylwia M. Niedziółka1Łukasz Markiewicz2Tomasz Uśpieński3Brygida Baran4Katarzyna Chojnowska5Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, PolandGli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttranslational modifications and intracellular transport. We also discuss how Gli proteins interact with co-activators and co-repressors to fine-tune the expression of Hedgehog target genes. Finally, we provide an overview of the regulation of developmental processes and tissue regeneration by Gli proteins and discuss how these proteins are involved in cancer progression, both through canonical regulation via the Hedgehog pathway and through cross-talk with other signaling pathways.https://www.mdpi.com/2073-4409/8/2/147Hedgehog signalingGli proteinsposttranslational modificationsprimary ciliacancerdevelopmental signalingmorphogen signalingnuclear import |
| spellingShingle | Paweł Niewiadomski Sylwia M. Niedziółka Łukasz Markiewicz Tomasz Uśpieński Brygida Baran Katarzyna Chojnowska Gli Proteins: Regulation in Development and Cancer Cells Hedgehog signaling Gli proteins posttranslational modifications primary cilia cancer developmental signaling morphogen signaling nuclear import |
| title | Gli Proteins: Regulation in Development and Cancer |
| title_full | Gli Proteins: Regulation in Development and Cancer |
| title_fullStr | Gli Proteins: Regulation in Development and Cancer |
| title_full_unstemmed | Gli Proteins: Regulation in Development and Cancer |
| title_short | Gli Proteins: Regulation in Development and Cancer |
| title_sort | gli proteins regulation in development and cancer |
| topic | Hedgehog signaling Gli proteins posttranslational modifications primary cilia cancer developmental signaling morphogen signaling nuclear import |
| url | https://www.mdpi.com/2073-4409/8/2/147 |
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