Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome
It has been known that inositols function as insulin second messengers and mediate different insulin-dependent processes and are a valid natural, non-pharmaceutical alternative to contrast insulin-resistance as well as associated metabolic syndrome in women with Polycystic ovarian disease (PCOS). Se...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2018-01-01
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| Series: | The EuroBiotech Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/ebtj-2018-0006 |
| _version_ | 1818731861002682368 |
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| author | Malvasi Antonio Tinelli Andrea Baldini Domenico Iannitti Rossana G. Fioretti Bernard |
| author_facet | Malvasi Antonio Tinelli Andrea Baldini Domenico Iannitti Rossana G. Fioretti Bernard |
| author_sort | Malvasi Antonio |
| collection | DOAJ |
| description | It has been known that inositols function as insulin second messengers and mediate different insulin-dependent processes and are a valid natural, non-pharmaceutical alternative to contrast insulin-resistance as well as associated metabolic syndrome in women with Polycystic ovarian disease (PCOS). Several studies also have shown positive effects of resveratrol in reducing glucose and lipid concentrations in patients. Recently, clinical evidence has proven that an D-chiro-inositol/resveratrol combination has a potential role to play in maintaining metabolic and endocrine health, however no large clinical trials have demonstrated the medical effectiveness of the combination, and the combined mode of action remains poorly discussed. Herein, we address the hypothesis of a synergistic mechanism adopted by D-chiro-inositol and resveratrol in reducing insulin resistance and hyperlipidemia and thus showing a greater therapeutic potential compared to treatment with inositol’s alone. |
| first_indexed | 2024-12-17T23:24:24Z |
| format | Article |
| id | doaj.art-79600ad9deae4cc59ac8d61df6ae235d |
| institution | Directory Open Access Journal |
| issn | 2564-615X |
| language | English |
| last_indexed | 2024-12-17T23:24:24Z |
| publishDate | 2018-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The EuroBiotech Journal |
| spelling | doaj.art-79600ad9deae4cc59ac8d61df6ae235d2022-12-21T21:28:49ZengSciendoThe EuroBiotech Journal2564-615X2018-01-0121353810.2478/ebtj-2018-0006ebtj-2018-0006Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndromeMalvasi Antonio0Tinelli Andrea1Baldini Domenico2Iannitti Rossana G.3Fioretti Bernard4Department of Obstetric & Gynecology, Santa Maria Hospital, GVM Care & Research, Bari, Italy; Laboratory of Human Anatomy, Department of Applied Mathematics, Moscow Institute of Physics and Technology (State University), Moscow Region, Russian FederationDivision of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Department of Obstetrics and Gynecology, Vito Fazzi Hospital, Lecce, ItalyCenter for Medically Assisted Fertilization, Momò Fertilife, Bisceglie, ItalyDepartment of Chemistry, Biology and Biotechnology, Via Elce di sotto, 06123, University of Perugia, Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, Via Elce di sotto, 06123, University of Perugia, Perugia, ItalyIt has been known that inositols function as insulin second messengers and mediate different insulin-dependent processes and are a valid natural, non-pharmaceutical alternative to contrast insulin-resistance as well as associated metabolic syndrome in women with Polycystic ovarian disease (PCOS). Several studies also have shown positive effects of resveratrol in reducing glucose and lipid concentrations in patients. Recently, clinical evidence has proven that an D-chiro-inositol/resveratrol combination has a potential role to play in maintaining metabolic and endocrine health, however no large clinical trials have demonstrated the medical effectiveness of the combination, and the combined mode of action remains poorly discussed. Herein, we address the hypothesis of a synergistic mechanism adopted by D-chiro-inositol and resveratrol in reducing insulin resistance and hyperlipidemia and thus showing a greater therapeutic potential compared to treatment with inositol’s alone.https://doi.org/10.2478/ebtj-2018-0006resveratrolinositolsinsulin and metabolic syndrome |
| spellingShingle | Malvasi Antonio Tinelli Andrea Baldini Domenico Iannitti Rossana G. Fioretti Bernard Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome The EuroBiotech Journal resveratrol inositols insulin and metabolic syndrome |
| title | Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| title_full | Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| title_fullStr | Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| title_full_unstemmed | Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| title_short | Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| title_sort | nutraceutical prospective the synergetic mechanism of action of inositols and resveratrol on metabolic syndrome |
| topic | resveratrol inositols insulin and metabolic syndrome |
| url | https://doi.org/10.2478/ebtj-2018-0006 |
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