The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Altera...
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/129 |
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| author | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Abhijit Dey Achsha Babu Kaviyarasi Renu Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Nehal Elsherbiny Amira M. Elsherbini Alsamman M. Alsamman Hatem Zayed Abilash Valsala Gopalakrishnan |
| author_facet | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Abhijit Dey Achsha Babu Kaviyarasi Renu Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Nehal Elsherbiny Amira M. Elsherbini Alsamman M. Alsamman Hatem Zayed Abilash Valsala Gopalakrishnan |
| author_sort | Anirban Goutam Mukherjee |
| collection | DOAJ |
| description | As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it. |
| first_indexed | 2024-03-09T11:42:34Z |
| format | Article |
| id | doaj.art-7960e28388264bada0d173235bc8799a |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:34Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-7960e28388264bada0d173235bc8799a2023-11-30T23:29:23ZengMDPI AGMetabolites2218-19892023-01-0113112910.3390/metabo13010129The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A ReviewAnirban Goutam Mukherjee0Uddesh Ramesh Wanjari1Sandra Kannampuzha2Reshma Murali3Arunraj Namachivayam4Raja Ganesan5Abhijit Dey6Achsha Babu7Kaviyarasi Renu8Balachandar Vellingiri9Gnanasambandan Ramanathan10George Priya Doss C.11Nehal Elsherbiny12Amira M. Elsherbini13Alsamman M. Alsamman14Hatem Zayed15Abilash Valsala Gopalakrishnan16Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of KoreaDepartment of Life Sciences, Presidency University, Kolkata 700073, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, IndiaStem Cell and Regenerative Medicine/Translational Research, Department of Zoology, School of Basic Sciences, Central University of Punjab (CUPB), Bathinda 151401, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Integrative Biology, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura 35516, EgyptDepartment of Genome Mapping, Molecular Genetics and Genome Mapping Laboratory, Agricultural Genetic Engineering Research Institute, Giza 12619, EgyptDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, IndiaAs a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it.https://www.mdpi.com/2218-1989/13/1/129PCOSmetabolomicsmetagenomicsmicrobiometherapy |
| spellingShingle | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Abhijit Dey Achsha Babu Kaviyarasi Renu Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Nehal Elsherbiny Amira M. Elsherbini Alsamman M. Alsamman Hatem Zayed Abilash Valsala Gopalakrishnan The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review Metabolites PCOS metabolomics metagenomics microbiome therapy |
| title | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
| title_full | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
| title_fullStr | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
| title_full_unstemmed | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
| title_short | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
| title_sort | implication of mechanistic approaches and the role of the microbiome in polycystic ovary syndrome pcos a review |
| topic | PCOS metabolomics metagenomics microbiome therapy |
| url | https://www.mdpi.com/2218-1989/13/1/129 |
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