Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma
Abstract Background The purpose of this study was to compare between contrast-enhanced computer tomography (CE CT) and 18F-FDG PET/CT in the detection of extranodal involvement in lymphoma and to correlate between SUVmax of the extranodal lesion and the hottest LN. One hundred patients with patholog...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-09-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43055-019-0011-1 |
| _version_ | 1819203302801276928 |
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| author | Amal Ibrahim Ahmed Othman Merhan Nasr Moustafa Abdel-Kawi |
| author_facet | Amal Ibrahim Ahmed Othman Merhan Nasr Moustafa Abdel-Kawi |
| author_sort | Amal Ibrahim Ahmed Othman |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to compare between contrast-enhanced computer tomography (CE CT) and 18F-FDG PET/CT in the detection of extranodal involvement in lymphoma and to correlate between SUVmax of the extranodal lesion and the hottest LN. One hundred patients with pathologically proven lymphoma underwent whole body 18F-FDG PET/CT and CECT scans. Images were compared regarding the ability of detection of extranodal lymphomatous sites. Kappa agreement was applied to find the degree of agreement between both modalities. Pearson’s correlation was used for correlating SUVmax of the extranodal lesions and hottest LN. The degree of FDG uptake was correlated with histopathological type. Results There was a poor agreement between PET/CT and CECT in the detection of extranodal sites (k = 0.32). There was a significant positive moderate correlation between SUVmax of the extranodal lesions and hottest LN (r = 0.45). PET/CT study resulted in up staging of 10% and down staging of 5% of cases. Conclusion In lymphoma staging, FDG PET/CT enables more detection of extranodal involved sites that show normal morphology at CECT. It differentiates lymphomatous infiltration from benign causes of increased FDG uptake with subsequent proper disease staging. |
| first_indexed | 2024-12-23T04:17:46Z |
| format | Article |
| id | doaj.art-7963457e4ce6408498c177b6ec1ed823 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-23T04:17:46Z |
| publishDate | 2019-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-7963457e4ce6408498c177b6ec1ed8232022-12-21T18:00:21ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622019-09-0150111310.1186/s43055-019-0011-1Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphomaAmal Ibrahim Ahmed Othman0Merhan Nasr1Moustafa Abdel-Kawi2Department of Radiology and Nuclear Medicine, Faculty of Medicine, Ain Shams UniversityDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Ain Shams UniversityDepartment of Radiology, Faculty of Medicine, Helwan UniversityAbstract Background The purpose of this study was to compare between contrast-enhanced computer tomography (CE CT) and 18F-FDG PET/CT in the detection of extranodal involvement in lymphoma and to correlate between SUVmax of the extranodal lesion and the hottest LN. One hundred patients with pathologically proven lymphoma underwent whole body 18F-FDG PET/CT and CECT scans. Images were compared regarding the ability of detection of extranodal lymphomatous sites. Kappa agreement was applied to find the degree of agreement between both modalities. Pearson’s correlation was used for correlating SUVmax of the extranodal lesions and hottest LN. The degree of FDG uptake was correlated with histopathological type. Results There was a poor agreement between PET/CT and CECT in the detection of extranodal sites (k = 0.32). There was a significant positive moderate correlation between SUVmax of the extranodal lesions and hottest LN (r = 0.45). PET/CT study resulted in up staging of 10% and down staging of 5% of cases. Conclusion In lymphoma staging, FDG PET/CT enables more detection of extranodal involved sites that show normal morphology at CECT. It differentiates lymphomatous infiltration from benign causes of increased FDG uptake with subsequent proper disease staging.http://link.springer.com/article/10.1186/s43055-019-0011-118-FDG PET/CTExtra nodalLymphomaSUVmax |
| spellingShingle | Amal Ibrahim Ahmed Othman Merhan Nasr Moustafa Abdel-Kawi Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma The Egyptian Journal of Radiology and Nuclear Medicine 18-FDG PET/CT Extra nodal Lymphoma SUVmax |
| title | Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma |
| title_full | Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma |
| title_fullStr | Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma |
| title_full_unstemmed | Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma |
| title_short | Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma |
| title_sort | beyond lymph nodes 18f fdg pet ct in detection of unusual sites of extranodal lymphoma |
| topic | 18-FDG PET/CT Extra nodal Lymphoma SUVmax |
| url | http://link.springer.com/article/10.1186/s43055-019-0011-1 |
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