Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction
Although capillary leak syndrome has a high mortality rate, its trigger, diagnosis, and treatment remain a challenge to clinicians because of the poor understanding of its mechanism and lack of treatment guidelines. With the extended use of immune checkpoint inhibitors in modern oncology, immune che...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454821000047 |
| _version_ | 1819102667568316416 |
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| author | Haixia Qin, MD, PhD Brittany Vlaminck, CNP Itunu Owoyemi, MBBS Sandra M. Herrmann, MD Nelson Leung, MD Svetomir N. Markovic, MD, PhD |
| author_facet | Haixia Qin, MD, PhD Brittany Vlaminck, CNP Itunu Owoyemi, MBBS Sandra M. Herrmann, MD Nelson Leung, MD Svetomir N. Markovic, MD, PhD |
| author_sort | Haixia Qin, MD, PhD |
| collection | DOAJ |
| description | Although capillary leak syndrome has a high mortality rate, its trigger, diagnosis, and treatment remain a challenge to clinicians because of the poor understanding of its mechanism and lack of treatment guidelines. With the extended use of immune checkpoint inhibitors in modern oncology, immune checkpoint inhibitor–associated immune-related adverse events have also expanded. We present a case of pembrolizumab-induced capillary leak syndrome and lymphatic capillary dysfunction in which the patient had an excellent clinical response to a tailored treatment strategy. |
| first_indexed | 2024-12-22T01:38:12Z |
| format | Article |
| id | doaj.art-7965301576fc4a07bc21373ffd1b2f4a |
| institution | Directory Open Access Journal |
| issn | 2542-4548 |
| language | English |
| last_indexed | 2024-12-22T01:38:12Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj.art-7965301576fc4a07bc21373ffd1b2f4a2022-12-21T18:43:19ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482021-06-0153670674Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary DysfunctionHaixia Qin, MD, PhD0Brittany Vlaminck, CNP1Itunu Owoyemi, MBBS2Sandra M. Herrmann, MD3Nelson Leung, MD4Svetomir N. Markovic, MD, PhD5Department of Medicine, Mayo Clinic, Rochester, MNDepartment of Medicine, Mayo Clinic, Rochester, MNDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MNDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MNDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MNDivision of Oncology, Mayo Clinic, Rochester, MN; Correspondence: Address to Svetomir N. Markovic, MD, PhD, Division of Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.Although capillary leak syndrome has a high mortality rate, its trigger, diagnosis, and treatment remain a challenge to clinicians because of the poor understanding of its mechanism and lack of treatment guidelines. With the extended use of immune checkpoint inhibitors in modern oncology, immune checkpoint inhibitor–associated immune-related adverse events have also expanded. We present a case of pembrolizumab-induced capillary leak syndrome and lymphatic capillary dysfunction in which the patient had an excellent clinical response to a tailored treatment strategy.http://www.sciencedirect.com/science/article/pii/S2542454821000047 |
| spellingShingle | Haixia Qin, MD, PhD Brittany Vlaminck, CNP Itunu Owoyemi, MBBS Sandra M. Herrmann, MD Nelson Leung, MD Svetomir N. Markovic, MD, PhD Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction |
| title_full | Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction |
| title_fullStr | Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction |
| title_full_unstemmed | Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction |
| title_short | Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction |
| title_sort | successful treatment of pembrolizumab induced severe capillary leak syndrome and lymphatic capillary dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2542454821000047 |
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