A computational investigation of the ventilation structure and maximum rate of metabolism for a physiologically based pharmacokinetic (PBPK) model of inhaled xylene

A computational investigation of the ventilation structure and maximum rate of metabolism for a physiologically based pharmacokinetic (PBPK) model of inhaled xylene

Physiologically based pharmacokinetic (PBPK) models are systems of ordinary differential equations that estimate internal doses following exposure to toxicants. Most PBPK models use standard equations to describe inhalation and concentrations in blood. This study extends previous work investigating...

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Bibliographic Details
Main Authors: Karen A Yokley, Jaclyn Ashcraft, Nicholas S Luke
Format: Article
Language:English
Published: Bulgarian Academy of Sciences, Institute of Mathematics and Informatics 2019-02-01
Series:Biomath
Subjects:
PBPK modeling, xylene
Online Access:http://www.biomathforum.org/biomath/index.php/biomath/article/view/1270

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