Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway

Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway

Infantile hemangioma (IH) is among the most prevalent benign vascular tumours in infants. The pathogenesis of IH mainly involves abnormal proliferation of vascular endothelial cells and the formation of new vessels. Itraconazole was shown to be effective in treating IH; however, the mechanism underl...

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Bibliographic Details
Main Authors: Jianyong Dong, Jun Cui, Xuanxuan Shi, Tao Wang, Shaohua Liu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Itraconazole
Hemangioma
Hedgehog signaling pathway
Proliferation
Apoptosis
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023064526

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http://www.sciencedirect.com/science/article/pii/S2405844023064526

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