Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Several naturally occurring dioxins, including 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD), synthesized by red algae, have been detected in the marine environment. As 1,3,7-TriBDD is accumulated in mussels and fish, predators, such as marine birds, are exposed to this congener, similar to anthropo...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322003785 |
| _version_ | 1811252447165808640 |
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| author | Jae Gon Park Hisato Iwata Nguyen Minh Tue Tatsuya Kunisue Eun-Young Kim |
| author_facet | Jae Gon Park Hisato Iwata Nguyen Minh Tue Tatsuya Kunisue Eun-Young Kim |
| author_sort | Jae Gon Park |
| collection | DOAJ |
| description | Several naturally occurring dioxins, including 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD), synthesized by red algae, have been detected in the marine environment. As 1,3,7-TriBDD is accumulated in mussels and fish, predators, such as marine birds, are exposed to this congener, similar to anthropogenic dioxins (including 2,3,7,8-tetrachlorodibenzo-p-dioxin TCDD). However, little is known about the impact of 1,3,7-TriBDD exposure on the bird health. To understand the effects of 1,3,7-TriBDD on birds, the phenotypic effects and hepatic transcriptome were investigated in chicken (Gallus gallus) embryos treated with 27 μM (2.9 ng/g egg) and 137 μM (14.4 ng/g egg) 1,3,7-TriBDD. The blood glucose levels in the 1,3,7-TriBDD-treated groups were lower than those in the control group. The transcriptome analysis of 6520 sequences in the 27 and 137 μM 1,3,7-TriBDD-treated groups identified 733 and 596 differentially expressed genes (DEGs). Cytochrome P450 1A4 and 1A5 were also identified as DEGs, suggesting that the aryl hydrocarbon receptor is activated by this congener. Pathway and network analyses with DEGs suggested that 1,3,7-TriBDD may induce carcinogenic effects and metabolic alterations. These results were similar to the effects on TCDD-treated embryos. Nevertheless, the overall transcriptome results suggested that compared with TCDD, 1,3,7-TriBDD has a unique impact on insulin- and peroxisome-signaling pathways in chicken embryos. Differences in altered transcriptome profiles between 1,3,7-TriBDD- and TCDD-treated embryos may lead to different phenotypic effects: less severe effects of 1,3,7-TriBDD and more fatal effects of TCDD. Collectively, these findings warrant the further assessment of the hazard and risk of 1,3,7-TriBDD on marine animals, considering increased exposure due to climate change. |
| first_indexed | 2024-04-12T16:34:42Z |
| format | Article |
| id | doaj.art-796867043fe5480c901a778414057015 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-12T16:34:42Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-796867043fe5480c901a7784140570152022-12-22T03:25:01ZengElsevierEcotoxicology and Environmental Safety0147-65132022-06-01237113538Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxinJae Gon Park0Hisato Iwata1Nguyen Minh Tue2Tatsuya Kunisue3Eun-Young Kim4Department of Biology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul 130–701, Republic of KoreaCenter for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790–8577, JapanCenter for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790–8577, JapanCenter for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790–8577, JapanDepartment of Biology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul 130–701, Republic of Korea; Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790–8577, Japan; Correspondence to: Department of Biology and Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul 130–701, Republic of Korea.Several naturally occurring dioxins, including 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD), synthesized by red algae, have been detected in the marine environment. As 1,3,7-TriBDD is accumulated in mussels and fish, predators, such as marine birds, are exposed to this congener, similar to anthropogenic dioxins (including 2,3,7,8-tetrachlorodibenzo-p-dioxin TCDD). However, little is known about the impact of 1,3,7-TriBDD exposure on the bird health. To understand the effects of 1,3,7-TriBDD on birds, the phenotypic effects and hepatic transcriptome were investigated in chicken (Gallus gallus) embryos treated with 27 μM (2.9 ng/g egg) and 137 μM (14.4 ng/g egg) 1,3,7-TriBDD. The blood glucose levels in the 1,3,7-TriBDD-treated groups were lower than those in the control group. The transcriptome analysis of 6520 sequences in the 27 and 137 μM 1,3,7-TriBDD-treated groups identified 733 and 596 differentially expressed genes (DEGs). Cytochrome P450 1A4 and 1A5 were also identified as DEGs, suggesting that the aryl hydrocarbon receptor is activated by this congener. Pathway and network analyses with DEGs suggested that 1,3,7-TriBDD may induce carcinogenic effects and metabolic alterations. These results were similar to the effects on TCDD-treated embryos. Nevertheless, the overall transcriptome results suggested that compared with TCDD, 1,3,7-TriBDD has a unique impact on insulin- and peroxisome-signaling pathways in chicken embryos. Differences in altered transcriptome profiles between 1,3,7-TriBDD- and TCDD-treated embryos may lead to different phenotypic effects: less severe effects of 1,3,7-TriBDD and more fatal effects of TCDD. Collectively, these findings warrant the further assessment of the hazard and risk of 1,3,7-TriBDD on marine animals, considering increased exposure due to climate change.http://www.sciencedirect.com/science/article/pii/S01476513220037851,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD)Natural dioxin2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)DioxinsChick embryoTranscriptome |
| spellingShingle | Jae Gon Park Hisato Iwata Nguyen Minh Tue Tatsuya Kunisue Eun-Young Kim Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin Ecotoxicology and Environmental Safety 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD) Natural dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Dioxins Chick embryo Transcriptome |
| title | Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| title_full | Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| title_fullStr | Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| title_full_unstemmed | Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| title_short | Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| title_sort | effects of 1 3 7 tribromodibenzo p dioxin a natural dioxin on chicken embryos comparison with effects of 2 3 7 8 tetrachlorodibenzo p dioxin |
| topic | 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD) Natural dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Dioxins Chick embryo Transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322003785 |
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